The aqueous extract of Gymnema sylvestre leaves (GSE) tested on various inflammatory models showed anti-inflammatory activity by significantly inhibiting carrageenan-induced rat paw oedema and peritoneal ascites in mice. GSE elevated liver enzymes (e.g. γ-glutamyl transpeptidase (γ-GT) and Superoxide dismutase (SOD)) showing a protective mechanism against the release of slow-reacting substances and free radicals. GSE did not inhibit granuloma formation and related biochemical indices, such as hydroxyproline and collagen. GSE in high doses did not affect the integrity of the gastric mucosa and appears to be a less gastrotoxic anti-inflammatory agent when compared with other non-steroidal anti-inflammatory agents.
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Diwan, P.V., Margaret, I. & Ramakrishna, S. Influence of Gymnema sylvestre on inflammation. Inflammopharmacology 3, 271–277 (1995). https://doi.org/10.1007/BF02659124
- Gymnema sylvestre
- Plant extract
- γ-glutamyl transpeptidase
- Superoxide dismutase