The aqueous extract of Gymnema sylvestre leaves (GSE) tested on various inflammatory models showed anti-inflammatory activity by significantly inhibiting carrageenan-induced rat paw oedema and peritoneal ascites in mice. GSE elevated liver enzymes (e.g. γ-glutamyl transpeptidase (γ-GT) and Superoxide dismutase (SOD)) showing a protective mechanism against the release of slow-reacting substances and free radicals. GSE did not inhibit granuloma formation and related biochemical indices, such as hydroxyproline and collagen. GSE in high doses did not affect the integrity of the gastric mucosa and appears to be a less gastrotoxic anti-inflammatory agent when compared with other non-steroidal anti-inflammatory agents.
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Thakur RS, Puri HS, Akthar H. Major medicinal plants in India. CIMAP, Lucknow. 1989.
Khare AK, Tondon RN, Tewari JP. Hypoglycemic activity of an indigenous drug(Gymnema sylvestre, ‘GURMAR’) in normal and diabetic persons. Ind J Physiol Pharmacol. 1983;27:257–8.
Shanmugasundaram KR, Panneerselvam C. Insulinotropic activity ofGymnema sylvestre R.Br., an Indian medical herb used in controlling diabetes mellitus. Pharmacol Res Commun. 1981;13:475–86.
Stocklin W. Gymnemagenin, Struktur und O-Isopropylidenderivate. Helv Chim Acta. 1969;52:365.
Diwan PV, Singh AK. Antiinflammatory activity of ‘Soymida febrifuga’ (Mansa rohini) in rats and mice. Phytother Res. 1993;7:255–6.
Diwan PV, Kulkarni DR. Antiinflammatory activity of nandrolone phenylpropionate. Ind J Exp Biol. 1983;21:569–71.
Diwan PV, Kulkarni, DR. Effects of nonsteroidal antiinflammatory agents (NSAIA’s) on wound healing. Ind J Exp Biol. 1986;24:640–3.
Urushidani T, Okabe S, Takauchi K, Takagi K. Effects of various amino acids in indomethacin induced gastric ulcers in rats. Jpn J Pharmacol. 1977;27:316–9.
Robert A, Nezamis JE, Lancaster C, Hanchar A. Cytoprotection by prostaglandins in rats: Prevention of gastric necrosis produced by alcohol, HC1, NaOH, hypertonic NaCl and thermal injury. Gastroenterology. 1979;77:433–43.
Boelsterli U, Zbinden G. Assay of gamma glutamyl transpeptidase in fine needle aspiration biopsy samples. In: Zbinden G, ed. Fine Needle Aspiration Biopsy of Rat Liver. New York: Pergamon Press; 1980:56–62.
Niwa Y, Kanoh T, Sakane T, Soh H, Kawai S, Miyachi Y. The ratio of lipid peroxide to Superoxide dismutase activity in the skin lesions of patients with severe skin disease. An accurate prognostic indicator. Life Sci. 1987;40:921–7.
Berg RA. Determination of 3- and 4-hydroxyproline. Meth Enzymol. 1982;82:372–80.
Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein estimation with bovine serum albumin as standard. J Biol Chem. 1951;193:265–75.
Örning L, Hammarström S. Kinetics of the conversion of leukotriene C by γ-glutamyl transpeptidase. Biochem Biophys Res Commun. 1982;106:1304–9.
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Diwan, P.V., Margaret, I. & Ramakrishna, S. Influence of Gymnema sylvestre on inflammation. Inflammopharmacology 3, 271–277 (1995). https://doi.org/10.1007/BF02659124
- Gymnema sylvestre
- Plant extract
- γ-glutamyl transpeptidase
- Superoxide dismutase