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Studies on the cellular mechanisms of action of positive and negative inotropic agents

  • Cellular And Subcellular Mechanisms, Energy Turnover
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Summary

We have reviewed the mechanism by which drugs that elevate cyclic AMP level modify myocardial contractility. We have presented preliminary evidence about the mechanism by which muscarinic agonists antagonize the effects of these drugs. Finally, we suggest that the protein phosphorylation experiments, particularly if done in dispersed myocytes, could be an efficient and cost-effective method of screening drugs which may act by elevating intracellular levels of cyclic AMP.

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References

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Authors and Affiliations

  1. Department of Medicine, Indiana University School of Medicine, 46240, Indianapolis, Indiana, USA

    A. M. Watanabe M.D., F. Green & Z. Ahmad

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  1. A. M. Watanabe M.D.
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  2. F. Green
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  3. Z. Ahmad
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Watanabe, A.M., Green, F. & Ahmad, Z. Studies on the cellular mechanisms of action of positive and negative inotropic agents. Basic Res Cardiol 84, 19–22 (1989). https://doi.org/10.1007/BF02650343

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  • DOI: https://doi.org/10.1007/BF02650343

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