Abstract
2-Hydroxy-5-methyl-6-ethoxycarbonylpyrazolo(1,5-a)pyrimidine (PP), a conversion product of pyrazophos, shows considerable toxicity toUstilago maydis, when administered to this fungus in a solution at pH<5. Evidence was obtained thatU. maydis may convert pyrazophos in to PP, and that the latter compound is the toxic principle responsible for the action of pyrazophos.
By UV-irradiation of sporidia no PP-resistant mutants were obtained. This does not support the hypothesis that this toxicant acts by specific inhibition of one enzyme system.
Samenvatting
2-Hydroxy-5-methyl-6-ethoxycarbonylpyrazolo(1,5-a)pyrimidine (PP), een omzettingsprodukt van pyrazofos, was in aanzienlijke mate toxisch voorUstilago maydis, wanneer toegediend in een oplossing die een pH<5 had. Aanwijzingen werden verkregen dat ookU. maydis in staat is pyrazofos om te zetten in PP en dat de laatste verbinding verantwoordelijk is voor de werking van pyrazofos.
Na UV-bestraling van sporidiën werden geen mutanten verkregen, die resistent waren tegen PP. De hypothese dat de werking van PP zou berusten op de specifieke remming van één enzymsysteem, wordt hierdoor niet gesteund.
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Georgopoulos, S.G., Geerligs, J.W.G. & Dekker, J. Sensitivity of Ustilago maydis to pyrazophos and one of its conversion products, and failure to induce resistance with UV-treatment. Netherlands Journal of Plant Pathology 81, 38–41 (1975). https://doi.org/10.1007/BF02650326
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DOI: https://doi.org/10.1007/BF02650326