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Negative regulators of the interleukin-1 system: receptor antagonists and a decoy receptor

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International Journal of Clinical and Laboratory Research

Abstract

The IL-1 system includes 2 agonists, α and β, processing and transport molecules, receptor antagonists, signalling receptor, a decoy receptor and an accessory molecule. Negative pathways of regulation include the antagonists, of which 3 isoforms have been cloned and the type II “decoy” receptor. Molecules that regulate inflammation and immunity coordinatively affect different components of the system. The complexity of the system and the existence of unique pathways of negative regulation, the antagonists and the decoy receptor, emphasize the need for a tight control of the production and action of IL-1.

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Authors and Affiliations

  1. Istituto di Ricerche Farmacologiche “Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy

    A. Mantovani, M. Muzio, P. Ghezzi & M. Introna

  2. Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy

    A. Mantovani

  3. Department of Immunology and Microbiology, Pharmacia Research Center, Nerviano, Milan, Italy

    F. Colotta

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  1. A. Mantovani
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  2. M. Muzio
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Mantovani, A., Muzio, M., Ghezzi, P. et al. Negative regulators of the interleukin-1 system: receptor antagonists and a decoy receptor. Int J Clin Lab Res 26, 7–14 (1996). https://doi.org/10.1007/BF02644768

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