Abstract
An increase in the linoleic to oleic acid ratio by an increase in the percentage of the polyunsaturated ω6 family of fatty acids in culinary fats and a decrease in the consumption of cholesterol-rich food were believed necessary as a prerequisite to early intervention in coronary heart disease. A decrease in total fat consumption also has been recommended. However, a decrease in the percentage of fat in the diet may not be nutritionally sound, as it may only increase the percentage of carbohydrates consumed and, thus, the synthesis of the ω9 family of fatty acids from the surfeit calories. It may be more judicious to decrease the total number of calories through less consumption of a well balanced diet. Furthermore, as thetrans-fatty acids, which are formed during hydrogenation, are not discriminated against completely by acyl-glycerol-3-phosphoryl-choline transferase or acyl coenzyme A cholesteryl transferase, it would be, from a biological viewpoint, advantageous to eliminatetrans-fatty acids from both stick and tub type margarines.
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References
Glazier, W.H., Sci. Amer. 228:13 (1973).
Culliton, B.J., Science 179:1305 (1973).
Potter, V.R., “Proceedings of the Twenty-second Annual Symposium on Fundamental Cancer Research,” Madison, Wisc., 1968, p. 587.
Fieser, L.F., and M. Fieser, in “Natural Products Related to Phenanthrene,” Reinhold Publishing, New York, N.Y., 1949, p. 330.
Miller, E.C., and J.A. Miller, Ann. Rev. Biochem. 28:291 (1959).
Pearce, M.L., and S. Dayton, Lancet 1:464 (1971).
Nichaman, M.Z., R.E. Olson, and C.C. Sweeley, Amer. J. Clin. Nutr. 20:1070 (1967).
Sgoutas, D.S., and F.A. Kummerow, in “The Symposium: Dairy Lipids and Lipid Metabolism,” Avi Publishing, Westport, Conn., 1968, pp. 116–134.
Reiser, R., Amer. J. Clin. Nutr. 26:524 (1973).
Klenk, E., Experientia 17:199 (1961).
Klenk, E., JAOCS 42:580 (1965).
Klenk, E., Advan. Lipid Res. 3:1 (1965).
Egwim, P.O., and F.A. Kummerow, J. Lipid Res. 13:500 (1972).
Pudelkewicz, C., J. Senfert, and R.T. Holman, J. Nutr. 94:138 (1968).
Privett, O.S., and M.L. Blank, JAOCS 41:292 (1964).
Walker, B.L., J. Nutr. 100:355 (1970).
Gidez, L.I., Biochem. Biophys. Res. Commun. 14:413 (1964).
Walker, B.L., J. Nutr. 92:23 (1967).
Walker, B.L., Ibid. 94:469 (1968).
Chapman, D., N.F. Owens, and D.A. Walker, Biochim. Biophys. Acta 120:148 (1966).
Mulder, E., and L.L.M. Van Deenen, Ibid. 106:106 (1965).
Demel, R.A., L.L.M. Van Deenen, and B.A. Pethica, Ibid. 135:11 (1967).
Eibl, H., R.A. Demel, and L.L.M. Van Deenen, J. Colloid Interface Sci. 29:381 (1969).
Burr, G.O., and M.M. Burr, J. Biol. Chem. 82:345 (1929).
Holman, R.T., Fed. Proc. 23:1062 (1964).
McMillan, G.C., M.D. Silver, and B.I. Weigensberg, Arch. Pathol. 76:106 (1963).
Weigensberg, B.I., and G.C. McMillan, Exp. Molec. Pathol. 3:201 (1964).
Weigensberg, B.I., and G.C. McMillan, J. Nutr. 83:314 (1964).
Coots, R.H., J. Lipid Res. 5:473 (1964).
Anderson, R.L., and R.H. Coots, Biochim. Biophys. Acta 144:525 (1967).
Blank, M.L., and O.S. Privett, J. Lipid Res. 4:470 (1963).
Knipprath, W.G., and J.F. Mead, JAOCS 41:437 (1964).
Selinger, Z., and R.T. Holman, Biochem. Biophys. Acta 106:56 (1965).
DeTomas, M.E., R.R. Brenner, and R.O. Reluffo, Ibid. 70:472 (1963).
Lands, W.E.M., M.L. Blank, L.J. Nutter, and O.S. Privett, Lipids 1:224 (1966).
Holman, R.T., Proc. Soc. Exp. Biol. Med. 76:100 (1951).
Mattson, F.H., J. Nutr. 71:366 (1960).
Privett, O., and M.L. Blank, JAOCS 41:292 (1964).
Lands, W.E.M. Ibid. 42:465 (1965).
Sgoutas, D.S., Biochemistry 9:1826 (1970).
Sgoutas, D.S., Biochim. Biophys. Acta 164:317 (1968).
Goller, H.J., D.S. Sgoutas, I.A. Ismail, and F.D. Gunstone, Biochemistry 9:3072 (1970).
Goodman, D.S., D. Deykin, and T. Shiratori, J. Biol. Chem. 239:1335 (1964).
Swell, L., M.D. Law, and C.R. Treadwell, Arch. Biochem. Biophys. 104:128 (1964).
Sgoutas, D.S., and F.A. Kummerow, Amer. J. Clin. Nutr. 23:1111 (1970).
Egwim, P.O., and F.A. Kummerow, J. Nutr. 102:783 (1972).
Kummerow, F.A., T. Mizuguchi, T. Arima, S.C. Yeh, and B.H. Cho, “Proceedings of the Third International Congress on Atherosclerosis,” West Berlin, Germany, October 1973 (In press).
Johnston, P.V., O.C. Johnson, and F.A. Kummerow, Science 126:698 (1957).
Takayasu, K., K. Okuda, and I. Yoshikawa, Lipids 5:743 (1970).
Raggatt, P.R., L.L. Engel, and T. Symington, Ibid. 7:474 (1972).
Peron, F.G., and S.B. Koritz, J. Biol. Chem. 235:1625 (1960).
Peron, F.G., Ibid. 236:1764 (1969).
Gidez, L.I., and E. Foller, J. Lipid Res. 10:656 (1969).
Hayashida, T., and O.N. Portman, Amer. J. Physiol. 197:893 (1950).
Egwim, P.O., and F.A. Kummerow, Paper presented at AOCS Spring Meeting, New Orleans, La., April 1973.
Eisenstein, A., Amer. J. Clin. Nutr. 26:113 (1973).
Research Committee, Lancet 2:693 (1968).
Bitman, J., H.K. Goering, L.P. Dryden, T.R. Wrenn, and C.H. Gordon, J. Dairy Sci. 55:714 (1972).
Weiss, J.F., E.C. Naber, and R.M. Johnson, J. Nutr. 93:153 (1967).
White, P.L., J. Amer. Med. Assoc. 223:1272 (1973).
De Kruyff, B., R.A. Demel, A.J. Slotboom, L.L.M. Van Deenen, and A.F. Rosenthal, Biochim. Biophys. Acta 307:1 (1973).
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One of five papers presented at the symposium, “Status of Fat in Food and Nutrition,” AOCS Fall Meeting, Chicago, September 1973.
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Kummerow, F.A. Current studies on relation of fat to health. J Am Oil Chem Soc 51, 255–259 (1974). https://doi.org/10.1007/BF02642631
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DOI: https://doi.org/10.1007/BF02642631