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The common cold


  1. 1.

    Gwaltney JM Jr. Historical eras of the common cold. In: Root RK, Sande MA, eds. Viral Infections: Diagnosis, Treatment and Prevention. New York: Churchill Livingstone, 1993;1–13.

    Google Scholar 

  2. 2.

    Jackson GG. The Medical Research Council Common Cold Unit. Harvard Hospital, Salisbury, Wilts, England. Rev Infect Dis. 1989;11:1020–1.

    PubMed  CAS  Google Scholar 

  3. 3.

    Andrewes CH. Adventures among viruses: III. The puzzle of the common cold. Rev Infect Dis. 1989;11:1022–8.

    PubMed  CAS  Google Scholar 

  4. 4.

    Gwaltney JM Jr. The common cold. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases, 4th ed. New York: Churchill Livingstone, 1995;561–6.

    Google Scholar 

  5. 5.

    Couch KB. The common cold: control? J Infect Dis. 1984;150:167–73.

    PubMed  CAS  Google Scholar 

  6. 6.

    Monto AS, Ullman BM. Acute respiratory illness in an American community: the Tecumseh study. JAMA. 1974;227:164–9.

    PubMed  Article  CAS  Google Scholar 

  7. 7.

    Monto AS, Bryan ER, Ohmit S. Rhinovirus infections in Tecumseh, Michigan: frequency of illness and number of serotypes. J Infect Dis. 1987;156:43–9.

    PubMed  CAS  Google Scholar 

  8. 8.

    Rossmann MG, Arnold E, Erickson JW, et al. Structure of a human common cold virus and functional relationship to other picornaviruses. Nature. 1985;317:145–53.

    PubMed  Article  CAS  Google Scholar 

  9. 9.

    Smith TJ, Kremer MJ, Luo M, et al. The site of attachment in human rhinovirus 14 for antiviral agents that inhabit uncoating. Science. 1986;133:1286–93.

    Article  Google Scholar 

  10. 10.

    Winther B, Gwaltney JM Jr, Mygind N. Sites of rhinovirus recovery after point inoculation of the upper airway. JAMA. 1986;156:1763.

    Article  Google Scholar 

  11. 11.

    Douglas RG Jr, Lindgren KM, Couch RB. Exposure to cold environment and rhinovirus common cold. Failure to demonstrate effect. N Engl J Med. 1968;279:742–7.

    Article  Google Scholar 

  12. 12.

    Cohen S, Tyrrell DA, Smith AP. Psychological stress and susceptibility to the common cold. N Engl J Med. 1991;325:606–12.

    PubMed  CAS  Article  Google Scholar 

  13. 13.

    Stone AA, Bovbjerg DH, Neale JM, et al. Development of common cold symptoms following experimental rhinovirus infection is related to prior stressful life event. Beh Med. 1992;18:115–20.

    CAS  Article  Google Scholar 

  14. 14.

    Winther B. Effects on the nasal mucosa of upper respiratory viruses (common cold). Danish Med Bull. 1994;41:193–204.

    PubMed  CAS  Google Scholar 

  15. 15.

    Naclerio RM, Proud D, Lichtenstein LM, et al. Kinins are generated during experimental rhinovirus colds. J Infect Dis. 1988;157:133–42.

    PubMed  CAS  Google Scholar 

  16. 16.

    Proud D, Naclerio RM, Gwaltney JM Jr., Hendley JO. Kinins are generated in nasal secretions during natural rhinovirus colds. J Infect Dis. 1990;161:120–3.

    PubMed  CAS  Google Scholar 

  17. 17.

    Proud D, Gwaltney JM Jr, Hendley JO, Dinarello CA, Gillis S, Schleimer RP. Increased levels of interleukin-1 are detected in nasal secretions of volunteers during experimental rhinovirus colds. J Infect Dis. 1994;169:1007–13.

    PubMed  CAS  Google Scholar 

  18. 18.

    Noah TL, Henderson FW, Wortman JA, et al. Nasal cytokine production in viral acute respiratory infection of childhood. J Infect Dis. 1995;171:584–92.

    PubMed  CAS  Google Scholar 

  19. 19.

    Gwaltney JM Jr, Hendley JO. Rhinovirus transmission. One if by air, two if by hand. Am J Epidemiol. 1978;107:357–61.

    PubMed  Google Scholar 

  20. 20.

    Hendley JO, Gwaltney JM Jr. Mechanisms of transmission of rhinovirus infections. Epidemiol Rev. 1988;10:242–58.

    Google Scholar 

  21. 21.

    Gwaltney JM Jr, Moskalski PB, Hendley JO. Hand-to-hand transmission of rhinovirus colds. Ann Intern Med. 1978;88:463–7.

    PubMed  Google Scholar 

  22. 22.

    Dick EC, Jennings LC, Mink KA, Wartgow CD, Inhorn SL. Aerosol transmission of rhinovirus colds. J Infect Dis. 1987;156:442–8.

    PubMed  CAS  Google Scholar 

  23. 23.

    D’Alessio DJ, Meschievitz CK, Peterson JA, Dick CR, Dick EC. Short-duration exposure and the transmission of rhinovirus colds. J Infect Dis. 1984;150:189–94.

    PubMed  CAS  Google Scholar 

  24. 24.

    Meschievitz CK, Schultz SB, Dick EC. A model for obtaining predictable natural transmission of rhinoviruses in human volunteers. J Infect Dis. 1984;150:195–200.

    PubMed  CAS  Google Scholar 

  25. 25.

    Warshauer DM, Dick EC, Mandel AD, Flynn TC, Jerde RS. Rhinovirus infections in an isolated Antarctic station: transmission of the viruses and susceptibility of the population. Am J Epidemiol. 1989;129:319–40.

    PubMed  CAS  Google Scholar 

  26. 26.

    Foy HM, Cooney MK, Hall C, Malmgren J, Fox JP. Case-to-case intervals of rhinovirus and influenza virus infections in households. J Infect Dis. 1988;157:180–2.

    PubMed  CAS  Google Scholar 

  27. 27.

    Ansari SA, Springthorpe VS, Sattar JA, Rivard S, Rahman M. Potential role of hands in the spread of respiratory viral infections: studies with human parainfluenza virus 3 and rhinovirus 14. J Clin Microbiol. 1991;29:2115–9.

    PubMed  CAS  Google Scholar 

  28. 28.

    Hendley JO, Wenzel RP, Gwaltney JM Jr. Transmission of rhinovirus colds by self-inoculation. N Engl J Med. 1973;288:1361–4.

    PubMed  CAS  Article  Google Scholar 

  29. 29.

    Levandowski RA, Ou DW, Jackson GG. Acute-phase decrease of T lymphocyte subsets in rhinovirus infection. J Infect Dis. 1986;153:743–8.

    PubMed  CAS  Google Scholar 

  30. 30.

    Hsia J, Goldstein AL, Simon GL, Sztein M, Hayden FG. Peripheral blood mononuclear cell interleukin-2 and interferon-gamma production, cytotoxicity, and antigen-stimulated blastogenesis during experimental rhinovirus infection. J Infect Dis. 1990;162:591–7.

    PubMed  CAS  Google Scholar 

  31. 31.

    Sung BS. Chonmaitree T, Broemeling LD, et al. Association of rhinovirus infection with poor bacteriologic outcome of bacterial-viral otitis media. Clin Infect Dis. 1993;17:38–42.

    PubMed  CAS  Google Scholar 

  32. 32.

    Elkhatieb A, Hipskind G, Woerner D, Hayden FG. Middle ear abnormalities during natural rhinovirus colds in adults. J Infect Dis. 1993;168:618–21.

    PubMed  CAS  Google Scholar 

  33. 33.

    Gwaltney JM Jr, Phillips CD, Miller RD, Riker DK. Computed tomographic study of the common cold. N Engl J Med. 1994;330:25–30.

    PubMed  Article  Google Scholar 

  34. 34.

    Turner BW, Cail WS, Hendley JO, et al. Physiologic abnormalities in the paranasal sinuses during experimental rhinovirus colds. J Allergy Clin Immunol. 1992;90:474–8.

    PubMed  Article  CAS  Google Scholar 

  35. 35.

    Al-Nakib W, Tyrrell DA. Drugs against rhinoviruses. J Antimicrob Chemother. 1992;30:115–7.

    PubMed  Article  CAS  Google Scholar 

  36. 36.

    Hayden FG, Gwaltney JM Jr. Intranasal interferon-alpha 2 treatment of experimental rhinoviral colds. J Infect Dis. 1984;150:174–80.

    PubMed  CAS  Google Scholar 

  37. 37.

    Samo TC, Greenberg SB, Couch RB, et al. Efficacy and tolerance of intranasally applied recombinant leukocyte A interferon in normal volunteers. J Infect Dis. 1983;148:535–42.

    PubMed  CAS  Google Scholar 

  38. 38.

    Farr BM, Gwaltney JM Jr, Adams K, Hayden FG. Intranasal interferon-alpha 2 for prevention of natural rhinovirus colds. Antimicrob Agents Chemother. 1984;26:31–4.

    PubMed  CAS  Google Scholar 

  39. 39.

    Hayden FG, Hipskind GJ, Woerner DH, et al. Intranasal pirodavir (R77, 975) treatment of rhinovirus colds. Antimicrob Agents Chemother 1995;39:290–4.

    PubMed  CAS  Google Scholar 

  40. 40.

    Graham NMH, Burell CJ, Douglas RM, Debelle P, Davies L. Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirus-infected volunteers. J Infect Dis. 1990;162:1277–82.

    PubMed  CAS  Google Scholar 

  41. 41.

    Sperber SJ, Hendley JO, Hayden FG, Riker DK, Sorrentino JV, Gwaltney JM Jr. Effects of naproxen on experimental rhinovirus colds: a randomized, double-blind, controlled trial. Ann Intern Med. 1992;117:37–41.

    PubMed  CAS  Google Scholar 

  42. 42.

    Farr BM, Gwaltney JM Jr, Handley JO, et al. A randomized controlled trial of glucocorticoid prophylaxis against experimental rhinovirus infection. J Infect Dis. 1990;162:1173–7.

    PubMed  CAS  Google Scholar 

  43. 43.

    Howard JC Jr, Kantner TR, Lilienfield LS, et al. Effectiveness of antihistamines in the symptomatic management of the common cold. JAMA. 1979;242:2414–7.

    PubMed  Article  Google Scholar 

  44. 44.

    Gaffey MJ, Kaiser DL, Hayden FG. Ineffectiveness of oral terfenadine in natural colds: evidence against histamine as a mediator of common cold symptoms. Pediatr Infect Dis J. 1988;7:223–8.

    PubMed  CAS  Article  Google Scholar 

  45. 45.

    Berkowitz RB, Tinkelman DG. Evaluation of oral terfenadine for treatment of the common cold. Ann Allergy. 1991;67:593–7.

    PubMed  CAS  Google Scholar 

  46. 46.

    Gwaltney JM Jr, Park J, Paul RA, Edelman D, O’Connor RR, Turner RB. A controlled trial of clemastine fumarate in experimental rhinovirus colds [abstract H41]. Abstracts of the 34th ICAAC. Washington, DC: American Society for Microbiology, 1994.

    Google Scholar 

  47. 47.

    Borum P, Olsen L, Winther B, Mygind N. Ipratropium nasal spray: a new treatment for rhinorrhea in the common cold. Am Rev Respir Dis. 1981;123:418–20.

    PubMed  CAS  Google Scholar 

  48. 48.

    Akerlund A, Klint T, Olen L, Rundcrantz H. Nasal decongestant effect of oxymetazoline in the common cold: an objective dose-response study in 106 patients. J Laryngol Otol. 1989;103:743–6.

    PubMed  CAS  Google Scholar 

  49. 49.

    Berkowitz RB, Connell JT, Dietz AJ, Greenstein JM, Tinkelman DG. The effectiveness of the nonsedating antihistamine loratidine plus pseudoephedrine in the symptomatic management of the common cold. Ann Allergy. 1989;63:336–9.

    PubMed  CAS  Google Scholar 

  50. 50.

    Gwaltney JM Jr. Combined antiviral and antimediator treatment of rhinovirus colds. J Infect Dis. 1992;166:776–82.

    PubMed  Google Scholar 

  51. 51.

    Pinnock CB, Graham NM, Mylvaganam A, Douglas RM. Relationship between milk intake and mucus production in adult volunteers challenged with rhinovirus-2. Am Rev Respir Dis. 1990;141:352–6.

    PubMed  CAS  Google Scholar 

  52. 52.

    Tyrrell D, Barrow I, Arthur J. Local hyperthermia benefits natural and experimental common colds. BMJ. 1989;298:1280–3.

    PubMed  CAS  Article  Google Scholar 

  53. 53.

    Macknin MI, Mathew S, Medendorp S. Effect of inhaling heated vapor in symptoms of the common cold. JAMA. 1990;264:989–91.

    PubMed  Article  CAS  Google Scholar 

  54. 54.

    Forstall GJ, Macknin ML, Yen-Lieberman BR, Medendrop SV. Effect of inhaling heated vapor on symptoms of the common cold. JAMA. 1994;271:1109–11.

    PubMed  Article  CAS  Google Scholar 

  55. 55.

    Farr BM, Conner EM, Betts RF, Oleske J, Minnefor A, Gwaltney JM Jr. Two randomized controlled trials of zinc gluconate lozenge therapy of experimentally induced rhinovirus colds. Antimicrob Agents Chemother. 1987;31:1183–7.

    PubMed  CAS  Google Scholar 

  56. 56.

    Douglas RM, Miles HB, Moore BW, Ryan P, Pinnock CB. Failure of effervescent zinc acetate lozenges to alter the course of upper respiratory tract infections in Australian adults. Antimicrob Agents Chemother. 1987;31:1263–5.

    PubMed  CAS  Google Scholar 

  57. 57.

    Godfrey JC, Sloane BC, Smith PS, Turco JN, Mercer N, Godfrey NJ. Zinc gluconate and the common cold: a controlled clinical study. J Int Med Res. 1992;20:234–46.

    PubMed  CAS  Google Scholar 

  58. 58.

    Chalmers TC. Effects of ascorbic acid on the common cold. An evaluation of the evidence. Am J Med. 1975;58:532–6.

    PubMed  Article  CAS  Google Scholar 

  59. 59.

    Panusarn C, Stanley ED, Dirda V, Rubenis M, Jackson GG. Prevention of illness from rhinovirus infection by a topical interferon inducer. N Engl J Med. 1974;291:57–61.

    PubMed  CAS  Article  Google Scholar 

  60. 60.

    Hayden FG, Gwaltney JM Jr. Intranasal interferon alpha 2 for prevention of rhinovirus infection and illness. J Infect Dis. 1983;148:543–50.

    PubMed  CAS  Google Scholar 

  61. 61.

    Douglas RM, Moore BW, Miles HB, et al. Prophylactic efficacy of alpha 2-interferon against rhinovirus infections in the family setting. N Engl J Med. 1986;314:65–70.

    PubMed  CAS  Article  Google Scholar 

  62. 62.

    Monto AS, Schwartz SA, Albrecht JK. Ineffectiveness of postexposure prophylaxis of rhinovirus infection with low-dose intranasal alpha 2b interferon in families. Antimicrob Agents Chemother. 1989;33:387–90.

    PubMed  CAS  Google Scholar 

  63. 63.

    Sperber SJ, Levine PA, Sorrentino JV, Riker DK, Hayden FG. Ineffectiveness of recombinant interferon-beta serine nasal drops for prophylaxis of natural colds. J Infect Dis. 1989;160:700–5.

    PubMed  CAS  Google Scholar 

  64. 64.

    Schwartz AR, Toyo Y, Hornick RB, Tominaga S, Gleckman RA. Evaluation of the efficacy of ascorbic acid in prophylaxis of induced rhinovirus 44 infection in man. J Infect Dis. 1973;128:500–5.

    PubMed  CAS  Google Scholar 

  65. 65.

    Coulehan JL, Reisinger KS, Rogers KD, Bradley DW. Vitamin C prophylaxis in a boarding school. N Engl J Med. 1974;290:6–10.

    PubMed  CAS  Article  Google Scholar 

  66. 66.

    Coulehan JL, Eberhard S, Kapner L, Taylor F, Rogers K, Garry P. Vitamin C and acute illness in Navaho school children. N Engl J Med. 1976;295:973–7.

    PubMed  CAS  Article  Google Scholar 

  67. 67.

    Hayden GF, Hendley JO, Gwaltney JM Jr. The effect of placebo and virucidal paper handkerchiefs on viral contamination of the hand and transmission of experimental rhinoviral infection. J Infect Dis. 1985;152:403–7.

    PubMed  CAS  Google Scholar 

  68. 68.

    Dick EC, Hossain SU, Mink KA, et al. Interruption of transmission of rhinovirus colds among human volunteers using virucidal paper handkerchiefs. J Infect Dis. 1986;153:352–6.

    PubMed  CAS  Google Scholar 

  69. 69.

    Hayden GF, Deforest D, Hendley JO, Gwaltney JM Jr. Inactivation of rhinovirus on human fingers by virucidal activity of glutaric acid. Antimicrob Agents Chemother. 1984;26:928–9.

    PubMed  CAS  Google Scholar 

  70. 70.

    Benchley R. How to avoid colds. In: Benchley—Or Else. New York: Harper and Brothers, 1947; 164–6.

    Google Scholar 

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Correspondence to Bennett Lorber.

Additional information

From the Section of Infectious Diseases, Temple University School of Medicine and Hospital, Philadelphia, Pennsylvania.

Dr. Lorber is a Thomas M. Durant Professor of Medicine.

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Lorber, B. The common cold. J Gen Intern Med 11, 229–236 (1996).

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  • Cough
  • Antimicrob Agent
  • Common Cold
  • Nasal Secretion
  • Glutaric Acid