An attempt to determine protein denaturing potency of typical surfactants has been made by measuring specific rotation of bovine serum albumin. The potencies obtained were examined in relation to the intensities of skin roughness in vivo caused by the surfactants, and a noticeable correlation was found between them. This fact also suggested that the cause of skin roughness may be attributed to a certain extent to adsorption of surfactants. In addition, this technique is very useful in predicting the skin roughening potency of a surfactant without using human skin.
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Imokawa, G., Sumura, K. & Katsumi, M. Study on skin roughness caused by surfactants: II. Correlation between protein denaturation and skin roughness. J Am Oil Chem Soc 52, 484–489 (1975). https://doi.org/10.1007/BF02640737
- Bovine Serum Albumin
- Surfactant Concentration
- Specific Rotation
- Alkyl Sulfate