Abstract
Addition of polar substituents to unsaturated fatty acids or their methyl esters enhanced the adsorption affinity contributed by each unsaturation site to such an extent that the resulting derivatives could be easily separated by differential adsorption on a silica gel coating. Saturated and unsaturated fatty acids could be separated by thin layer chromatography after either bromination of their methyl esters or oxidation of their mixture into unsaturated esters, monoenoates, dienoates, and trienoates. Furthermore, it was possible to separate the configurational isomers of the hydroxystearic acids derived fromcis andtrans hydroxylation of oleic and linoleic acids.
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Partial support of these studies by Grant No. H-1819 from National Institutes of Health.
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Sgoutas, D., Kummerow, F.A. Thin-layer chromatographic separation of some bromo-and hydroxyderivatives of stearic acid. J Am Oil Chem Soc 40, 138–141 (1963). https://doi.org/10.1007/BF02640720
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DOI: https://doi.org/10.1007/BF02640720