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The function of vitamin B6 in fat metabolism

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Journal of the American Oil Chemists Society

Conclusion

It is evident that vitamin B6 serves as a physiological antioxidant. The mechanism cannot be dependent solely on the chemical structure of the vitamin. Despite the favorable arrangement of the substituents, pyridoxine and its derivatives show no, or only slight, antioxidative activityin vitro. The inactivation apparently results from the nature of the pyridine ring.

Vitamin B6 is one of the B vitamins which are required for the normal metabolism of the fats and essential fatty acids. However it still remains to be investigated whether the vitamin is directly associated with fat metabolism or whether the vitamin itself is responsible for the maximum function or the synthesis of enzymes involved.

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References

  1. Vilter, R. W., Mueller, J. F., Glazer, H. S., Jarrold, T., Abraham, J., Thompson, C., and Hawkins, V. R., J. Lab. and Clin. Med.,42, 335 (1953).

    CAS  Google Scholar 

  2. Rabinowitz, J. C., and Snell, E. E., J. Biol. Chem.,176, 1157 (1948).

    CAS  Google Scholar 

  3. Gunsalus, I. C., Bellamy, W. D., and Umbreit, W. W., J. Biol. Chem.,155, 685 (1944).

    CAS  Google Scholar 

  4. Rabinowitz, J. C., and Snell, E. E., J. Biol. Chem.,169, 643 (1947).

    CAS  Google Scholar 

  5. Rabinowitz, J. C., and Snell, E. E., Proc. Soc. Exptl. Biol. and Med.,70, 235 (1949).

    CAS  Google Scholar 

  6. Huff, J. W., and Perlzweig, W. A., J. Biol. Chem.,155, 345 (1944).

    CAS  Google Scholar 

  7. Scudi, J. V., Buhs, R. P., and Hood, D. B., J. Biol. Chem.,142, 323 (1942).

    CAS  Google Scholar 

  8. Sakuragi, T., and Kummerow, F. A., Arch. Biochem, and Biophys.,73, 43 (1958).

    Article  CAS  Google Scholar 

  9. Cunningham, E., and Snell, E. E., J. Biol. Chem.,158, 491 (1945).

    CAS  Google Scholar 

  10. Burr, G. O., and Barnes, R. H., Physiol. Revs.,23, 256 (1943).

    CAS  Google Scholar 

  11. Harris, S. A., Heyl, D., and Folkers, K., J. Am. Chem. Soc.,66, 2088 (1944).

    Article  CAS  Google Scholar 

  12. Heyl, D., J. Am. Chem. Soc.,70, 3434 (1948).

    Article  CAS  Google Scholar 

  13. Heyl, D., Luz, E., and Harris, S. A., J. Am. Chem. Soc.,73, 3437 (1951).

    Article  CAS  Google Scholar 

  14. Heyl, D., Harris, S. A., and Folkers, K., J. Am. Chem. Soc.,75, 653 (1953).

    Article  CAS  Google Scholar 

  15. Hove, E. L., and Harris, P. L., J. Nutrition,31, 699 (1946).

    CAS  Google Scholar 

  16. Sakuragi, T., and Kummerow, F. A., J. Am. Chem. Soc.,78, 839 (1956).

    Article  CAS  Google Scholar 

  17. Sakuragi, T., and Kummerow, F. A., J. Am. Oil Chemists' Soc.,35, 401 (1958).

    Article  CAS  Google Scholar 

  18. Van Fleet, D. S., Am. J. Botany,30, 678 (1943).

    Article  Google Scholar 

  19. Young, J. M. Jr., Dinning, J. S., and Day, P. L., Proc. Soc. Exptl. Biol. and Med.,89, 216 (1955).

    CAS  Google Scholar 

  20. Stoll, B. A., Radiology,68, 380 (1957).

    PubMed  CAS  Google Scholar 

  21. Tulpule, P. G., and Williams, J. N. Jr., J. Biol. Chem.,217, 229 (1955).

    PubMed  CAS  Google Scholar 

  22. Tulpule, P. G., and Patwardhan, V. N., Arch. Biochem. and Biophys.,39, 450 (1952).

    Article  CAS  Google Scholar 

  23. Witting, L. A., Nishida, T., Johnson, O. C., and Kummerow, F. A., J. Am. Oil Chemists' Soc.,34, 421 (1957).

    Article  CAS  Google Scholar 

  24. McHenry, E. W., and Gavin, G., J. Biol. Chem.,138, 471 (1941).

    CAS  Google Scholar 

  25. Sherman, H., “Pyridoxine and Fat Metabolism,” in “Vitamins and Hormones” by R. S. Harris and K. V. Thimann, ed., Vol. VIII, Academic Press, New York, 1950, p. 55.

    Google Scholar 

  26. Witten, P. W., and Holman, R. T., Arch. Biochem. and Biophys.,41, 266 (1952).

    Article  CAS  Google Scholar 

  27. Howton, D. R., Davis, R. H., and Nevenzel, J. C., J. Am. Chem. Soc.,76, 4970 (1954).

    Article  CAS  Google Scholar 

  28. Steinberg, G., Slaton, W. H. Jr., Howton, D. R., and Mead, J. F., J. Biol. Chem.,220, 257 (1956).

    PubMed  CAS  Google Scholar 

  29. Mead, J. F., Steinberg, G., and Howton, D. R., J. Biol. Chem.,205, 683 (1953).

    PubMed  CAS  Google Scholar 

  30. Steinberg, G., Slaton, W. H. Jr., Howton, D. R., and Mead, J. F., J. Biol. Chem.,224, 841 (1957).

    PubMed  CAS  Google Scholar 

  31. Mead, J. F., and Howton, D. R., J. Biol. Chem.,229, 575 (1957).

    PubMed  CAS  Google Scholar 

  32. Champougny, J., and Le Breton, E., Compt. rend. soc. biol.,141, 43 (1947);C.A., 41, 4819h.

    CAS  Google Scholar 

  33. Basnayake, V., and Sinclair, H. M., “The Effect of Deficiency of Essential Fatty Acids upon the Skin,” in “Biochemical Problems of Lipids” by G. Popjak and E. Le Breton, ed., Interscience, New York, 1956, p. 476.

    Google Scholar 

  34. Birch, T. W., J. Biol. Chem.,124, 775 (1938).

    CAS  Google Scholar 

  35. Sinclair, H. M., “Essential Fatty Acids and their Relation to Pyridoxine,” in “Lipid Metabolism” by R. T. Williams, ed., Cambridge University Press, Cambridge, 1952, p. 80.

    Google Scholar 

  36. Sinclair, H. M., Biochem. J.,51, xvi (1952).

    Google Scholar 

  37. Beaton, J. R., Beare, J. L., Beaton, G. H., and McHenry, E. W., J. Biol. Chem.,204, 715 (1953).

    PubMed  CAS  Google Scholar 

  38. Cheng, A. L. S., Ryan, M., Alfin-Slater, Roslyn B., and Deuel, H. J. Jr., J. Nutrition,52, 637 (1954).

    CAS  Google Scholar 

  39. Scott, L. D., and Tarleton, G. J., Radiology,47, 386 (1946).

    Google Scholar 

  40. Pult-Lorusso, T., Il. Farmaco (Pavia), Ed. Sci.,8, 711 (1953);C. A., 48, 7728i.

    CAS  Google Scholar 

  41. Schreiner, A. W., Rockwell, E., and Vilter, R. W., J. Invest. Dermat.,19, 95 (1952).

    Article  CAS  Google Scholar 

  42. Holden, J. T., and Holman, J.,J. Bacteriol., 73, 592 (1957).

    PubMed  CAS  Google Scholar 

  43. Holden, J. T., and Holman, J., Feder Proc.,16, 198 (1957).

    Google Scholar 

  44. Rinehart, J. F., and Greenberg, L. D., Am. J. Pathol.,25, 481 (1949).

    CAS  Google Scholar 

  45. Greenberg, L. D., and Rinehart, J. F., Proc. Soc. Exptl. Biol. and Med.,76, 580 (1951).

    CAS  Google Scholar 

  46. McFarland, W., A. M. A. Arch. Pathol.,55, 503 (1953).

    CAS  Google Scholar 

  47. Martens, F. W., and Hoskins, D. W., Circulation Res.,6, 159 (1958).

    PubMed  CAS  Google Scholar 

  48. Failey, R. B., Circulation Res.,6, 203 (1958).

    PubMed  CAS  Google Scholar 

  49. Deuel, H. J. Jr., Food Res.,20, 81 (1958).

    Google Scholar 

  50. Altschul, R., Hoffer, A., and Stephen, J. D., Arch. Bioichem. and Biophys.,54, 557 (1955).

    Google Scholar 

  51. Rinehart, J. F., and Greenberg, L. D., A.M.A. Arch. Pathol.,51, 12 (1951).

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Food Technology, University of Illinois, Urbana, Illinois

    Taketami Sakuragi

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  1. Taketami Sakuragi
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Sakuragi, T. The function of vitamin B6 in fat metabolism. J Am Oil Chem Soc 36, 251–253 (1959). https://doi.org/10.1007/BF02640070

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  • DOI: https://doi.org/10.1007/BF02640070

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