Skip to main content
Log in

Role of oleic acid in the metabolism of essential fatty acids

Journal of the American Oil Chemists Society

Cite this article


Groups of young male guinea pigs were fed diets containing corn oil, coconut oil, coconut oil plus elaidic acid, and coconut oil plus oleic acid. The oleic acid-fed group showed signs of essential fatty acid deficiency after four weeks and severe signs after eight weeks. The elaidic acid-fed group did not show these symptoms. It is proposed that oleic acid competes competitively with linoleic acid as a substrate for the enzymes involved in linoleate transformations when only a very limited supply of linoleic acid is available to the animals and oleic acid is made available in relatively large amounts.

A detailed analysis of the serum, liver, and adipose tissue lipid and a study of the incorporation of acetate-1-C14 into different lipids is presented.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others


  1. Kinsell, L.W., and Michaels, G.D., Fed. Proc.,14, 661 (1955).

    PubMed  CAS  Google Scholar 

  2. Ahrens, E.H., Jr., Hirsch, J., Insull, W. Jr., Tsaltas, T.T., Bloomstand, R., and Peterson, M.L., Lancet,1, 943 (1957).

    Article  Google Scholar 

  3. Sinclair, R.G., J. Biol. Chem.,111, 515 (1935).

    CAS  Google Scholar 

  4. Sinclair, R.G., J. Biol. Chem.,118, 131 (1937).

    Google Scholar 

  5. Sinclair, H.M., Lancet,1, 381 (1956).

    Google Scholar 

  6. Holman, R.T., and Jorgensen, Aaes E., Proc. Soc. Exp. Biol. Med.,93, 175 (1956).

    PubMed  CAS  Google Scholar 

  7. Mattson, F.H., J. Nutrition,71, 366 (1960).

    CAS  Google Scholar 

  8. Reid, M.E., and Briggs, G.M., J. Nutrition,51, 341 (1953).

    CAS  Google Scholar 

  9. Folch, J., Lees, M., and Sloane-Stanley, G.H., J. Biol. Chem.,226, 497 (1957).

    PubMed  CAS  Google Scholar 

  10. Hodgrson, T.S., Gordon, B.E., and Ackerman, M.E., Nucleonics,16, 89 (1958).

    Google Scholar 

  11. Mangold, H.K., and Malins, D.C., J. Am. Oil Chemists’ Soc.,37, 383 (1960).

    CAS  Google Scholar 

  12. Fulco, A.J., and Mead, J.F., J. Biol. Chem.,234, 1411 (1959).

    PubMed  CAS  Google Scholar 

  13. Bosshardt, D.K., Dryvokulsky, M., and Howe, E.E., J. Nutrition,69, 185 (1959).

    CAS  Google Scholar 

  14. Thomasson, H.J., Von Beers, G.J., Gottenbos, J.J., DeFongh, H., Keppler, J.G., and Sparrenboom, S., “Biochemistry of Lipids”, Pergamon Press, New York (1960).

    Google Scholar 

  15. Swell, L., Field, H. Jr., and Treadwell, C.R., Proc. Soc. Exp. Biol. Med.,104, 325 (1960).

    PubMed  CAS  Google Scholar 

  16. Tove, S.B., and Smith, F.H., J. Nutrition,71, 264 (1960).

    CAS  Google Scholar 

  17. Mead, J.F., J. Biol. Chem.,227, 1025 (1957).

    PubMed  CAS  Google Scholar 

  18. Reiser, R., Williams, M.C., and Sorrels, M.F., Arch. Biochem. Biophys.,86, 42 (1960).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Additional information

This paper is based on work supported in part by United States Public Health Grant No. HTS 5306 and by a grant from the Nutrition Foundation Inc., New York.

About this article

Cite this article

Dhopeshwarkar, G.A., Mead, J.F. Role of oleic acid in the metabolism of essential fatty acids. J Am Oil Chem Soc 38, 297–301 (1961).

Download citation

  • Received:

  • Issue Date:

  • DOI: