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Effect of dietary docosahexaenoic acid on brain composition and neural function in term infants

  • Fatty Acids and Brain Function
  • Published:
Lipids

Abstract

There is a need to determine whether there is a dietary requirement for docosahexaenoic acid (DHA, 22:6n-3) by term infants to achieve their full developmental potential. Studies of brain fatty acid composition demonstrated that infants who were breast fed had greater levels of cerebral cortex DHA than did infants who were formula fed, suggesting that DHA in the cerebrum is dependent on a supply in the diet. Some physiological studies reported that electrophysiological and behavioral assessments of visual function were improved in breast-fed infants relative to those fed formula and that this was related to the length of breast feeding. While some randomized studies of DHA supplementation of infant formula to term infants demonstrated that the visual function of formula-fed infants could be improved to breast-fed levels by adding DHA to formula, others failed to demonstrate an effect. Variations in dietary treatments and methods of assessment make comparison of the studies difficult. Further work is necessary to rigorously establish if there are long-term benefits of dietary DHA to the term infant.

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Abbreviations

AA:

arachidonic acid

ALA:

α-linolenic acid

DHA:

docosahexaenoic acid

EPA:

eicosapentaenoic acid

LA:

linoleic acid

LCPUFA:

long-chain polyunsaturated fatty acids

PCA:

post-conceptional age

VEP:

visually evoked potential.

References

  1. Neuringer, M., Anderson, G.J., and Connor, W.E. (1988) The Essentiality of n-3 Fatty Acids for the Development and Function of the Retina and Brain,Ann. Rev. Nutr. 8, 517–541.

    Article  CAS  Google Scholar 

  2. Clark, K.J., Makrides, M., Neumann, M.A., and Gibson, R.A. (1992) Determination of the Optimal Ratio of Linoleic Acid to α-Linolenic acid in Infant Formulas,J. Pediatr. 120, S151-S158.

    Article  PubMed  CAS  Google Scholar 

  3. Makrides, M., Gibson, R.A., and Simmer, K. (1993) The Effect of Dietary Fat on the Developing Brain,J. Paediatr. Child Health 29, 409–410.

    Article  PubMed  CAS  Google Scholar 

  4. Van Aerde, J.E., and Clandinin, M.T. (1993) Controversy in Fatty Acid Balance,Can. J. Physiol. Pharmacol. 71, 707–712.

    PubMed  Google Scholar 

  5. Gibson, R.A., Makrides, M., Neumann, M.A., Simmer, K., Mantzioris, E., and James, M.J. (1994) Ratios of Linoleic Acid to α-Linolenic Acid in Formulas for Term Infants,J. Pediatr. 125, S48-S55.

    PubMed  CAS  Google Scholar 

  6. Scientific Review Committee (1990) Lipids: Function and Composition, inNutrition Recommendations: The Report of the Scientific Review Committee, pp. 40–52, Minister of National Health and Welfare, Ottawa.

    Google Scholar 

  7. Aggett, P.J., Haschke, F., Henie, W., Hernell, O., Koletzko, B., Launiala, K., Rey, J., Rubino, A., Schöch, G., Senterre, J., and Tormo, R. (ESPGAN Committee on Nutrition) (1991) Comment on the Content and Composition of Lipids in Infant Formulas,Acta Paediatr. Scand. 80, 887–896.

    PubMed  CAS  Google Scholar 

  8. Retallack, S.J., Simmer, K., Makrides, M., and Gibson, R.A. (1994) Infant Weaning Practices in Adelaide: The Results of a Shopping Complex Survey,J. Paediatr. Child Health 30, 28–32.

    PubMed  CAS  Google Scholar 

  9. Jensen, C.I., Chen, H.M., Prager, T.C., Anderson, R.E., and Heird, W.C. (1995) Effect of Dietary C18∶2n−6/C18∶3n−3 Ratio in Term Infants,INFORM 6, 531 (Abstract).

    Google Scholar 

  10. Makrides, M., Neumann, M.A., Byard, R.W., Simmer, K., and Gibson, R.A. (1994) Fatty Acid Composition of Brain, Retina, and Erythrocytes in Breast- and Formula-Fed Infants,Am. J. Clin. Nutr. 60, 189–194.

    PubMed  CAS  Google Scholar 

  11. Uauy, R.D., Birch, D.G., Birch, E.E., Tyson, J.E., and Hoffman, D.R. (1990) Effect of Dietary Omega-3 Fatty Acids on Retinal Function of Very-Low-Birth-Weight Neonates,Pediatr. Res. 28, 485–492.

    Article  PubMed  CAS  Google Scholar 

  12. Birch, E.E., Birch, D.G., Hoffman, D.R., and Uauy, R. (1992) Dietary Essential Fatty Acid Supply and Visual Acuity Development,Invest. Ophthalmol. Vis. Sci. 32, 3242–3253.

    Google Scholar 

  13. Carlson, S.E., Werkman, S.H., Rhodes, P.G., and Tolley, E.A. (1993) Visual-Acuity Development in Healthy Preterm Infants: Effect of Marine-Oil Supplementation,Am. J. Clin. Nutr. 58, 35–42.

    PubMed  CAS  Google Scholar 

  14. Makrides, M., Simmer, K., Goggin, M., and Gibson, R.A. (1993) Erythrocyte Docosahexaenoic Acid Correlates with the Visual Response of Healthy, Term InfantsPediatr. Res. 33, 425–427.

    Article  PubMed  CAS  Google Scholar 

  15. Makrides, M., Neumann, M., Simmer, K., Pater, J., and Gibson, R., (1995) Are Long-Chain Polyunsaturated Fatty Acids Essential Nutrients in Infancy?,Lancet 345, 1463–1468.

    Article  PubMed  CAS  Google Scholar 

  16. Birch, D.G., Birch, E.E., Hoffman, D.R., and Uauy, R.D. (1992) Retinal Development in Very-Low-Birth-Weight Infants Fed Diets Differing in Omega-3 Fatty Acids,Invest. Ophthalmol. Vis. Sci. 33, 2365–2376.

    PubMed  CAS  Google Scholar 

  17. Carlson, S.E., Cooke, R.J., Werkman, S.H., and Tolley, E.A. (1992) First Year Growth of Preterm Infants Fed Standard Compared to Marine Oil n-3 Supplemented formula,Lipids 27, 901–907.

    Article  PubMed  CAS  Google Scholar 

  18. Janowsky, J.S., Scott, D.T., Wheeler, R.E., and Auestad, N. (1995) Fatty Acids Affect Early Language Development,Pediatr. Res. 37, 310A (Abstract).

    Article  Google Scholar 

  19. Auestad, N., Montalto, M.B., Wheeler, R.E., Fitzgerald, K.R., Hall, R.T., Neuringer, M., Connor, W.E., Hartmann, E.E., and Taylor, J.A. (1995) Visual Acuity, RBC Fatty Acids and Growth in Term Infants Fed Formulas with and without Long Chain Polyunsaturated Fatty Acids (LCP),Pediatr. Res. 37, 302A (Abstract).

    Google Scholar 

  20. Innis, S.M., Nelson, C.M., Rioux, M.F., and King, D.J. (1994) Development of Visual Acuity in Relation to Plasma and Erythrocyte Omega-6 and Omega-3 Fatty Acids in Healthy Term Gestation Infants,Am. J. Clin. Nutr. 60, 347–352.

    PubMed  CAS  Google Scholar 

  21. Carlson, S.E., Ford, A.J., Peeples, J.M., and Werkman, S.H. (1995) Visual Acuity in Term Infants Fed Human Milk or Randomly Assigned to a Formula with or without Long Chain n-3 and n-6 Fatty Acids, Pediatr. Res., in press.

  22. Uauy, R., Hoffman, D.R., Birch, E.E., Birch, D.G., Jameson, D.M., and Tyson, J. (1994) Safety and Efficacy of Omega-3 Fatty Acids in the Nutrition of Very Low Birth Weight Infants: Soy Oil and Marine Oil Supplementation of Formula,J. Pediatr. 124, 612–620.

    Article  PubMed  CAS  Google Scholar 

  23. Sanders, T.A.B., Ellis, F.R., and Dickerson, J.W.T. (1978) Studies of Vegans: The Fatty Acid Composition of Plasma Choline Phosphoglycerides, Erythrocytes, Adipose Tissue, and Breast Milk, and Some Indicators of Susceptibility to Ischemic Heart Disease in Vegans and Omnivore Controls,Am. J. Clin. Nutr. 31, 805–813.

    PubMed  CAS  Google Scholar 

  24. Gibson, R.A., Makrides, M., Neumann, M.A., and Simmer, K. (1995) Is DHA Supplementation Necessary During Lactation?Am. J. Clin. Nutr., Abstract, in press.

  25. Martinez, M. (1992) Tissue Levels of Polyunsaturated Fatty Acids During Early Human Development,J. Pediatr. 120, S129-S138.

    Article  PubMed  CAS  Google Scholar 

  26. Barker, D.J.P. (1993) The Intrauterine Origins of Cardiovascular Disease,Acta Paediatr. Suppl. 391, 93–99.

    Google Scholar 

  27. Fall, C.H.D., Vijayakumar, M., Barker, D.J.P., Osmond, C., and Duggleby, S. (1995) Weight in Infancy and Prevalence of Coronary Heart Disease in Adult Life,Br. Med. J. 310, 17–19.

    CAS  Google Scholar 

  28. Lucas, A., Morley, R., Cole, T.J., Lister, G., and Leeson-Payne, C. (1992) Breast Milk and Subsequent Intelligence Quotient in Children Born Preterm,Lancet 339, 261–264.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Paediatrics and Child Health, Flinders Medical Centre, 5042, Bedford Park, SA, Australia

    Robert A. Gibson, Mark A. Neumann & Maria Makrides

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  1. Robert A. Gibson
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  2. Mark A. Neumann
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  3. Maria Makrides
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Gibson, R.A., Neumann, M.A. & Makrides, M. Effect of dietary docosahexaenoic acid on brain composition and neural function in term infants. Lipids 31, S177–S181 (1996). https://doi.org/10.1007/BF02637072

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