Skip to main content
SpringerLink
Log in

Antioxidants, lipoprotein oxidation, and arterial function

  • Antioxidant Status and Peroxidation
  • Published:
Lipids

Abstract

Lipoproteins have an important influence on arterial tissues. High levels of low density lipoproteins (LDL) may inhibit arterial function in terms of the release of nitric oxide from the endothelium. This inhibition is enhanced by the oxidation of these lipoproteins which may occur during the development of atherosclerosis. Many of these effects are due to lipid oxidation products. The impairment of the release of nitric oxide and vasodilatation may be partially attenuated by antioxidants. LDL may also enhance the activity of blood platelets, especially when they are mildly oxidized. Oral administration of antioxidants may decrease the activation of platelets to a limited extent. Lipid peroxides may play a role in these processes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

HDL:

high density lipoproteins

LDL:

low density lipoproteins

mmLDL:

minimally oxidized LDL

nLDL:

native LDL

NO:

nitric oxide

oxLDL:

oxidized LDL

References

  1. Rice-Evans C.A., and Bruckdorfer, K.R. (1992) Free Radicals, Lipoproteins and Cardiovascular Dysfunction,Mole. Aspects Med. 13, 1–112.

    CAS  Google Scholar 

  2. Andrews, H.E., Bruckdorfer, K.R., Dunn, R.C., and Jacobs, M. (1987) Low-Density Lipoproteins Inhibit Endothelium-Dependent Relaxation in Rabbit Aorta,Nature. 327, 237–239.

    Article  PubMed  CAS  Google Scholar 

  3. Chowiencyk, P.J., Watts, G.F., Cockroft, J.R., and Ritter, J.M. (1992) Impaired Endothelium-Dependent Vasodilation of Forearm Resistance Vessels in Hypercholesterolaemia,Lancet 340, 1430–1432.

    Article  Google Scholar 

  4. Sorensen, K.E., Celermajer, D.S., Deanfield, J.E., and Macrae, D.J. (1994) Impairment of Endothelium-Dependent Dilation Is an Early Event in Children with Familial Hypercholesterolaemia and Is Related to the Lipoprotein (a) Level,J. Clin Invest. 93, 50–55.

    PubMed  CAS  Google Scholar 

  5. Jacobs, M., Plane, F., and Bruckdorfer, K.R. (1990) Native and Oxidised LDL Have Differential Inhibitory Effects on Endothelium Derived Relaxing Factor in Rabbit Aorta,Brit. J. Pharmacol. 100, 21–26.

    CAS  Google Scholar 

  6. Buckley, C., Bund, S., McTaggart, F., Bruckdorfer, K.R., Jacobs, M., and Oldham, A. (1993) Oxidised Low-Density Lipoproteins Inhibit Endothelium-Dependent Relaxations of Rabbit Coronary Arteries,Br. J. Pharmacol. 100, 222.

    Google Scholar 

  7. Minor, R.L., Myers, P.R., Guerra, R.J., Bates, J.N., and Harrison, D.G. (1990) Diet-Induced Atherosclerosis Increases the Release of Nitrogen Oxides from Rabbit Aorta,J. Clin. Invest. 86, 2109–2116.

    Article  PubMed  CAS  Google Scholar 

  8. Plane, F., Bruckdorfer, K.R., Kerr, P., Steuer, A., and Jacobs, M. (1992) Oxidative Modification of Low-Density Lipoproteins and the Inhibition of Relaxations mediated by Endothelium-Derived Nitric Oxide in Rabbit Aorta,Br. J. Pharmacol. 105, 216–222.

    PubMed  CAS  Google Scholar 

  9. Buckley, C., McManus, D., Bruckdorfer, K.R., and Jacobs, M. (1994) 9-Hydroxy- and 9-Hydroperoxy-Linoleic Acids Inhibit Endothelium-Dependent Relaxations of Rabbit Aorta,Br. J. Pharmacol. 112, 222.

    Google Scholar 

  10. Buckley, C., McManus, D., Bruckdorfer, K.R., and Jacobs, M. (1994) Hydroperoxy- and Hydroxy-Derivatives of Arachidonic Acid Inhibit Endothelium-Dependent Relaxation,Br. J. Pharmacol. 112, 222.

    Google Scholar 

  11. Gleeson, A.M., Bruckdorfer, K.R., and Jacobs, M. (1995) Oxysterols and Endothelium-Dependent Relaxations,Endothelium 2, S8.

    Google Scholar 

  12. Jacobs, M., Plane, F., and Bruckdorfer, K.R. (1993) Probucol and Other Antioxidants Prevent the Inhibition of Endothelium-Dependent Relaxation by Low-Density Lipoproteins,Atherosclerosis, 103, 73–79.

    Article  PubMed  Google Scholar 

  13. Bruckdorfer, K.R., Gleeson, A.M., Allot, C., and Jacobs, M. (1995) Regression of Atherosclerotic Lesions and the Associated Impairment of Vasodilation by Probucol,Endothelium 2, S10.

    Google Scholar 

  14. Bruckdorfer, K.R. (1989) The Effects of Plasma Lipoproteins on Platelet Responsiveness and on Platelet and Vascular Prostanoid Synthesis,Prostagland., Leukot. Essent. Fatty 38, 247–254.

    Article  CAS  Google Scholar 

  15. Naseem, K.M., Goodall, A.H., and Bruckdorfer, K.R. (1993) The Effects of Native Lipoproteins of Platelet Activation,Biochem. Soc. Trans. 21, 140S.

    Google Scholar 

  16. Naseem, K.M., and Bruckdorfer, K.R. (1995) Hydrogen Peroxide at Low Concentrations Strongly Enhances the Inhibitory Effect of Nitric Oxide on Platelets,Biochem J. 310, 149–153.

    PubMed  CAS  Google Scholar 

  17. Salonen, J.T., Salonen, R., Seppanen, K., Rinta-Kiikka, S., Kuukka, M., Korpela, H., Alfthan, G., Kantola, M., and Schalch, W. (1991) Effects of Antioxidant Supplementation on Platelet Function: A Randomized Pair-Matched, Placebo-Controlled, Double-Blind Trial in Men with Low Antioxidant Status,Am. J. Clin. Nutr. 53, 1222–1229.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Royal Free Hospital School of Medicine, Rowland Hill St., NW3 2PF, London, K

    K. Richard Bruckdorfer

Authors
  1. K. Richard Bruckdorfer
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Richard Bruckdorfer, K. Antioxidants, lipoprotein oxidation, and arterial function. Lipids 31, S83–S85 (1996). https://doi.org/10.1007/BF02637056

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02637056

Keywords

Search

Navigation