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Unchecked DNA synthesis and blocked cell division induced by methionine deprivation in a human prostate cancer cell line

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References

  1. Coalson, D. W.; Mecham, J. O.; Stern, P. H., et al. Reduced availability of endogenously synthesized methionine for S-adenosylmethionine formation in methionine-dependent cancer cells. Proc. Natl. Acad. Sci. USA 79:4248–4251; 1982.

    Article  PubMed  CAS  Google Scholar 

  2. Guo, H. Y.; Herrera, H.; Groce, A., et al. Expression of the biochemical defect of methionine dependence in fresh patient tumors in primary histoculture. Submitted.

  3. Hoffman, R. M. Altered methionine metabolism, DNA methylation, and oncogene expression in carcinogenesis: a review and synthesis. Biochem. Biophys. Acta 738:49–87; 1984.

    PubMed  CAS  Google Scholar 

  4. Hoffman, R. M.; Jacobsen, S. J. Reversible growth arrest in SV40-transformed human fibroblasts. Proc. Natl. Acad. Sci. USA 77(12):7306–7310; 1980.

    Article  PubMed  CAS  Google Scholar 

  5. Hoffman, R. M.; Monosov, A. Z.; Connors, K. M., et al. A general native-state method for determination of proliferation capacity of human normal and tumor tissues in vitro. Proc. Natl. Acad. Sci. USA 86:2013–2017; 1989.

    Article  PubMed  CAS  Google Scholar 

  6. Livingstone, L. R.; White, A.; Sprouse, J., et al. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell 70:923–935; 1992.

    Article  PubMed  CAS  Google Scholar 

  7. Mecham, J. O.; Rowitch, D.; Wallace, C. D., et al. The metabolic defect of methionine dependence occurs frequently in human tumor cell lines. Biochem. and Biophys. Res. Comm. 117(2):429–434; 1983.

    Article  CAS  Google Scholar 

  8. Stern, P. H.; Mecham, J. O.; Wallace, C. D., et al. Reduced free-methionine in methionine-dependent SV-40 transformed human fibroblasts synthesizing apparently normal amounts of methionine. J. Cell. Physiol. 117:9–14; 1983.

    Article  PubMed  CAS  Google Scholar 

  9. Stern, P. H.; Wallace, C. D.; Hoffman, R. M. Altered methionine metabolism occurs in all members of a set of diverse human tumor cell lines. J. Cell. Physiol. 119:29–34; 1984.

    Article  PubMed  CAS  Google Scholar 

  10. Stern, P. H.; Hoffman, R. M. Enhanced in vitro selective toxicity of chemotherapeutic agents for human cancer cells based on a metabolic defect. J. Natl. Cancer Inst. 76(4):629–639; 1986.

    PubMed  CAS  Google Scholar 

  11. Yin, Y.; Tainsky, M. A.; Bischoff, F. Z., et al. Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 70:937–948; 1992.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. AntiCancer Inc., 5325 Metro Street, 92110, San Diego, California

    Hui Yan Guo, Hector Herrera & Robert M. Hoffman

  2. Laboratory of Cancer Biology, University of California, 92093, San Diego La Jolla, California

    Robert M. Hoffman

Authors
  1. Hui Yan Guo
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  2. Hector Herrera
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  3. Robert M. Hoffman
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Guo, H.Y., Herrera, H. & Hoffman, R.M. Unchecked DNA synthesis and blocked cell division induced by methionine deprivation in a human prostate cancer cell line. In Vitro Cell Dev Biol - Animal 29, 359–361 (1993). https://doi.org/10.1007/BF02633982

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  • DOI: https://doi.org/10.1007/BF02633982

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