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Examination of cell toxicity and dosing regimen in an in vitro chromosomal aberration assay

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References

  1. Bhapkar, V. P. On the analysis of contingency tables with a quantitative response. Biometrics 24:329–338; 1968.

    Article  PubMed  CAS  Google Scholar 

  2. Buckton, K. E.; Evans, H. J., eds. Methods for the analysis of human chromosome aberrations. Geneva: World Health Organization; 1973.

    Google Scholar 

  3. E.E.C. Directive 67/548, Annex V, Part B. Methods for the determination of toxicity, B.10 Mutagenicity in vitro mammalian cytogenetic test, E.E.C. publication No. L251; 1984.

  4. Galloway, S. M.; Bloom, A. D.; Resnick, M., et al. Development of a standard protocol for in vitro cytogenetic testing with Chinese hamster ovary cells: comparison of results for 22 compounds in two laboratories. Environ. Mutagenesis 7:1–51; 1985.

    Article  CAS  Google Scholar 

  5. Galloway, S. M.; Deasy, D. A.; Bean, C. L., et al. Effects of high osmatic strength in chromosome aberrations, sister-chromatid exchanges and DNA strand breaks, and the relation to toxicity. Mutation Res. 189:15–25; 1987.

    Article  PubMed  CAS  Google Scholar 

  6. Gollapudi, B. B.; Sutcliff, D. J.; Sinha, A. K. Assessment of cytogenetic response to folic acid deprivation in rat lymphocyte. In Vitro 22:681–684; 1986.

    CAS  Google Scholar 

  7. Ishidate, M.; Odashima, S. Chromosome tests with 134 compounds on Chinese hamster cells in vitro—a screening for chemical carcinogens. Mutation Res. 48:337–354; 1977.

    PubMed  CAS  Google Scholar 

  8. Ishidate, M. Data book of chromosomal aberration testin vitro. Amsterdam: Elsevier; 1988.

    Google Scholar 

  9. Linscombe, V. A.; Gollapudi, B. B.; Sinha, A. K. Examination of cytogenetic damage and cytokinetics in streptomigrin-treated human lymphocytes. In Vitro Cell. Dev. Biol. 27A:603–605; 1991.

    PubMed  CAS  Google Scholar 

  10. MAFF/Shirasu, Y. The Japanese mutagenicity guidelines for pesticide registration. Mutation Res. 205:393–395; 1988.

    Article  PubMed  CAS  Google Scholar 

  11. Sinha, A. K.; Linscombe, V. A.; Gollapudi, B. B., et al. Evaluation of culture media for effects on cell cycle kinetics and incidence of chromosomal aberrations in human blood cells. Can. J. Genet. Cytol. 26:7–12; 1984.

    PubMed  CAS  Google Scholar 

  12. Sinha, A. K.; Gollapudi, B. B.; Linscombe, V. A., et al. Analysis forin vitro growth conditions, cytokinetics, and sister chromatid exchanges in lymphocytes cultured from the Sprague-Dawley rat. In Vitro 21:583–587; 1985.

    CAS  Google Scholar 

  13. Sinha, A. K.; Gollapudi, B. B.; Linscombe, V. A., et al. Utilization of rat lymphocytes for thein vitro chromosomal aberration assay. Mutagenesis 4:147–153; 1989.

    Article  PubMed  CAS  Google Scholar 

  14. Thilagar, A. K.; Kumaroo, P. U.; Kott, S. Effect of low pH caused by glacial acetic acid and hydrochloric acid on chromosomal aberrations in CHO cells. Toxicologist 4:51; 1984.

    Google Scholar 

  15. UKEMS/Scott, D.; Dean, B. J.; Danford, N. D., et al. Metaphase chromosome aberration assays. In: Kirkland, D. J., ed. Basic mutagenicity tests. New York, NY: Cambridge University Press; 1990:62.

    Google Scholar 

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Linscombe, V.A., Gollapudi, B.B., Bodner, K.M. et al. Examination of cell toxicity and dosing regimen in an in vitro chromosomal aberration assay. In Vitro Cell Dev Biol - Animal 29, 350–352 (1993). https://doi.org/10.1007/BF02633979

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