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Geographical variation in endocrine function and its relation to breast cancer incidence: Some general considerations

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Summary

Abnormalities in endocrine function are not a determinant of risk of breast cancer within countries, and racial differences in this function do not explain geographical variation in risk. It is suggested that hormonal status is related to tumor growth rates and hence to age at diagnosis, recurrence rates after primary treatment, and survival. Such evidence as there is points in this direction, but it still remains to be finally established whether the disease runs a similar course in all countries when patients are standardised for factors known to affect prognosis.

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References

  1. Miller AB, Bulbrook RD: UICC multidisciplinary project on breast cancer: the epidemiology, aetiology and prevention of breast cancer. Int J Cancer 37: 173–177, 1986

    Article  PubMed  CAS  Google Scholar 

  2. Moore JW, Thomas BS, Wang DY: Endocrine status and the epidemiology and clinical course of breast cancer. Cancer Surveys 5: 537–559, 1986

    PubMed  CAS  Google Scholar 

  3. Key TJA, Pike MC: The role of estrogens and progestagens in the epidemiology and prevention of breast cancer. Eur J Cancer Clin Oncol 24: 29–35, 1988

    Article  PubMed  CAS  Google Scholar 

  4. Bulbrook RD, Leake RE, George WD: Oestrogens in the initiation and promotion of breast cancer. Proc Royal Soc Edinburgh 95B: 67–76, 1989

    Google Scholar 

  5. Bulbrook RD, Thomas BS: Hormones are ambiguous risk factors for breast cancer. Acta Oncologia 28: 000–000, 1989

    CAS  Google Scholar 

  6. Morrison AS, Lowe CR, MacMahon B,et al.: Some international differences in treatment and survival in breast cancer. Int J Cancer 18: 269–273, 1976

    Article  PubMed  CAS  Google Scholar 

  7. Russo J, Tay LK, Russo IH: Differentiation of the mammary gland and susceptibility to carcinogenesis. Breast Cancer Res Treat 2: 5–73, 1982

    Article  PubMed  CAS  Google Scholar 

  8. Fournier D, Weber E, Hoeffken W,et al.: Growth rate of 147 mammary carcinomas. Cancer 45: 2198–2207, 1980

    Article  Google Scholar 

  9. Bulbrook RD, Swain MC, Wang DY,et al.: Breast cancer in Britain and Japan: Plasma oestradiol-17β, oestrone and progesterone, and their urinary metabolites in normal British and Japanese women. Eur J Cancer Clin Oncol 12: 725–735, 1976

    CAS  Google Scholar 

  10. Hayward JL, Greenwood FC, Glober G,et al.: Endocrine status in normal British, Japanese and Hawaiian-Japanese women. Eur J Cancer Clin Oncol 14: 1221–1228, 1978

    CAS  Google Scholar 

  11. Goldin BR, Adlercreutz H, Gorbach SL: The relationship between estrogen levels and diets of Caucasian American and Oriental immigrant women. Am J Clin Nutr 44: 945–951, 1986

    PubMed  CAS  Google Scholar 

  12. Moore JW, Clark GMG, Takatani O,et al.: Distribution of 17β-estradiol in the sera of normal British and Japanese women. J Natl Cancer Inst 71: 749–754, 1983

    PubMed  CAS  Google Scholar 

  13. Goodman MJ, Bulbrook RD, Moore JW: The distribution of estradiol in the sera of normal Caucasian, Chinese, Filipina, Hawaiian and Japanese women living in Hawaii. Eur J Cancer Clin Oncol 24: 1855–1860, 1988

    Article  PubMed  CAS  Google Scholar 

  14. The Anglo-Egyptian Collaborative Study. Serum hormone levels in breast cancer patients and controls in Egypt and Great Britain. Eur J Cancer Clin Oncol 24: 1329–1335, 1988

    Article  Google Scholar 

  15. LeMarchand L, Kolonel LN, Nomura AM: Breast cancer survival among Hawaiian Japanese and Caucasian women. Ten year rates and survival by place of birth. Am J Epidemiol 122: 571–578, 1985

    PubMed  CAS  Google Scholar 

  16. Dansey RD, Hessel PA, Browde S,et al.: Lack of a significant independent effect of race on survival in breast cancer. Cancer 61: 1908–1912, 1988

    Article  PubMed  CAS  Google Scholar 

  17. Ismael K: Unpublished observations.

  18. Allen DS, Bulbrook RD, Chaudary MA,et al.: Recurrence and survival rates in British and Japanese women with breast cancer. This volume

  19. Moolgavkar SH: Hormones and multistage carcinogenesis. Cancer Surveys 5: 635–648, 1986

    PubMed  CAS  Google Scholar 

  20. Henderson BE, Ross RK, Judd HL,et al.: Do regular ovulatory cycles increase breast cancer risk? Cancer 56: 1206–1212, 1985

    Article  PubMed  CAS  Google Scholar 

  21. Hayward JL, Carbone PP, Heuson J-C,et al.: Assessment of response to therapy in advanced breast cancer. Cancer 39: 1289–1294, 1977

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Imperial Cancer Research Fund Laboratory, Depts of Surgery and Biochemistry, University of Glasgow, Scotland

    R. D. Bulbrook

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  1. R. D. Bulbrook
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Bulbrook, R.D. Geographical variation in endocrine function and its relation to breast cancer incidence: Some general considerations. Breast Cancer Res Tr 18 (Suppl 1), S37–S40 (1991). https://doi.org/10.1007/BF02633525

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  • DOI: https://doi.org/10.1007/BF02633525

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