Summary
Crosslinking of [14C]l-tyrosine to at least five hamster melanoma cell surface proteins is reported. This effect was abolished by addition of nonradioactivel-tyrosine,l-phenylalanine, orl-dopa, but not byd-tyrosine, tyramine, dopamine, norepinephrine, or epinephrine. The above proteins can be purified by tyrosine-affinity chromatography. They have molecular weights different from proteins staining for dopa oxidase and proteins that bind anti-tyrosinase antibody in Western blots. It is suggested that they may be a hithergo unrecognized part of the cellular apparatus governing melanogenesis.
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Slominski, A. l-tyrosine-binding proteins on melanoma cells. In Vitro Cell Dev Biol – Animal 27, 735–738 (1991). https://doi.org/10.1007/BF02633219
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DOI: https://doi.org/10.1007/BF02633219