Immunisation of cattle in Zimbabwe usingTheileria Parva (boleni) without concurrent tetracycline therapy

Immunisation Du Betail Au Zimbabwe En UtilisantTheileria Parva (Boleni) Sans Traitement Par La Tetracycline

Immunizacion Del Ganado Bovino En Zimbabwe UtizandoTheileria Parva (Boleni) Sin Quimioterapia, Simultanea Con Tetraciclinas

Summary

Five hundred and ten cattle were immunised using theTheileria parva (Boleni) stock without concurrent chemotherapy with tetracycline on 2 farms in Zimbabwe, both of which had a history of theileriosis. The stabilate had been titrated in Friesian calves to determine a 50% protective dose (PD50) and 2 or 3 (PD50s) were used to immunise the cattle.

None of the cattle showed a clinical reaction following the immunisation procedure. However, the cattle were shown to have responded immunologically on testing for antibodies to aT. parva antigen in an indirect fluorescent antibody test. The immunised cattle were then exposed to a natural field challenge causing severe theileriosis in control cattle.

Immunisation against theileriosis without the need for concurrent chemotherapy is much less expensive than the infection and treatment method (US$2·72) compared to US$10·23 in the first year) and would be much more attractive to commercial and traditional farmers.

Résumé

510 têtes de bétail furent immunisées avecTheileria parva (Boleni) sans utilisation de tétracycline dans 2 fermes au Zimbabwe, dans lesquelles il y eut des cas de theilériosis. La titration de la souche fut effectuée chez des veaux de race frisonne pour déterminer la dose protégeant à 50% (PD50). 2 ou 3 doses furent alors utilisées pour immuniser le bétail.

Aucun animal ne présenta de signes cliniques après immunisation. Cependant une réponse immunologique fut observée après une étude sérologique par immunofluorescence indirecte. Le bétail immunisé fut alors exposé à une infection naturelle extérieure qui entraîna des cas sévères de theilériose chez les animaux de contrôle.

La vaccination sans utilisation de tétracycline est moins chère que la méthode traditionnelle (infection + traitement) (US$2,72 au leiu de US$10,23 dépensés la première année). Cette méthode devrait s’avérer financièrement plus attrayante pour les fermiers.

Resumen

Quinientas diez reses de ganado vacuno fueron immunizadas usando una cepa deT. parva sin quimioterapia simultánea con tetraciclinas en dos explotaciones ganaderas en Zimbabwe, ambas con historial de teileriosis.

El preparado había sido titulado en terneros de raza Frisia con el fin de determinar la Dosis Protectora 50 (DP50) y 2 ó 3 DP50 fueron empleadas para immunizar al ganado.

Ninguno de los bóvidos presentó signos clínicos a consecuencia del proceso de immunización. Sin embargo, se evidenció en éstos una respuesta immunológica al demostrarse anticuerpos contra un antígeno deT. parva en un test de fluoescencia indirecta. El ganado immunizado fue entonces expuesto a infección natural, la cual originó una teileriosis severa en el grupo de control.

La immunización contra la teileriosis sin el empleo simultáneo de quimioterapia es mucho menos cara que el método de infección y tratamiento (2·72 en comparación con 10·23 dólares USA durante el primer año) y sería mucho más atrayente para los ganaderos de explotaciones comerciales y tradicionales.

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Correspondence to R. G. Pegram.

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Kanhai, G.K., Pegram, R.G., Hargreaves, S.K. et al. Immunisation of cattle in Zimbabwe usingTheileria Parva (boleni) without concurrent tetracycline therapy. Trop Anim Health Prod 29, 92–98 (1997). https://doi.org/10.1007/BF02632324

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Keywords

  • Tetracycline
  • Concurrent Chemotherapy
  • Indirect Fluorescent Antibody Test
  • Clinical Reaction
  • East Coast Fever