Skip to main content

Advertisement

SpringerLink
Log in

Lethal hepatic failure in ulcerative colitis

  • Published:
Diseases of the Colon & Rectum

Summary

A case of fatal fatty metamorphosis of the liver in a patient with fulminant ulcerative colitis is presented.

The patient died in hepatic coma with normal serum ammonia. This unusual finding is related to previous colectomy.

The occurrence of liver disease in patients with ulcerative colitis, and the possible factors responsible for these severe histopathologic changes, are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Atkinson, M. and J. C. Goligher: Recurrent hepatic coma treated by colectomy and ileorectal anastomosis. Lancet.1: 460, 1960.

    Google Scholar 

  2. Bendandi, A.: Liver function in ulcerative colitis. Gastroenterologia.86: 658, 1956.

    PubMed  CAS  Google Scholar 

  3. Boden, R. W., J. G. Rankin, S. J. M. Goulston and W. Morrow: The liver in ulcerative colitis: The significance of raised serumalkaline-phosphatase levels. Lancet.2: 245, 1959.

    Article  PubMed  CAS  Google Scholar 

  4. Brooke, B. N., P. W. Dykes and F. C. Walker: A study of liver disorder in ulcerative colitis. Postgrad. M. J.37: 245, 1961.

    Google Scholar 

  5. Dammin, G. J.: Personal communication to the authors.

  6. Goodman, L. S. and A. Gilman: The Pharmacological Basis of Therapeutics. Ed. 2, New York, The Macmillan Company, 1955, pp. 1298; 1386.

    Google Scholar 

  7. Jones, G. W., A. H. Baggenstoss and J. A. Bargen: Hepatic lesions and dysfunction associated with chronic ulcerative colitis. Am. J. M. Sc.221: 279, 1951.

    Article  PubMed  CAS  Google Scholar 

  8. Jones, D. P. and C. S. Davidson: The treatment of hepatic coma. New England J. Med.267: 196, 1962.

    Article  CAS  Google Scholar 

  9. Kimmelstiel, P., H. L. Large, Jr., and H. D. Verner: Liver damage in ulcerative colitis. Am. J. Path.28: 259, 1962.

    Google Scholar 

  10. Kleckner, M. S., Jr., M. H. Stauffer, J. A. Bargen and M. B. Dockerty: Hepatic lesions in the living patient with chronic ulcerative colitis as demonstrated by needle biopsy. Gastroenterology.22: 13, 1952.

    PubMed  Google Scholar 

  11. McDermott, W. V., Jr., M. Victor and W. W. Point: Exclusion of the colon in the treatment of hepatic encephalopathy. New England J. Med.267: 850, 1962.

    Google Scholar 

  12. Pollard, H. M. and M. Block: Association of hepatic insufficiency with chronic ulcerative colitis. Arch. Int. Med.82: 159, 1948.

    CAS  Google Scholar 

  13. Popper, H. and F. Schaffner: Structure and Function. New York, McGraw-Hill Book Company, 1957, 777 pp.

    Google Scholar 

  14. Reynolds, V. H. and R. E. Wilson: Absence of recurrent ammonia intoxication following right hemicolectomy with anastomosis of the superior mesenteric vein to the inferior vena cava. Ann. Surg.154: 826, 1961.

    Article  PubMed  CAS  Google Scholar 

  15. Ross, J. R. and J. M. Swarts: Hepatic dysfunction and cirrhosis in chronic ulcerative colitis. Gastroenterology.10: 81, 1948.

    PubMed  CAS  Google Scholar 

  16. Sherlock, S.: Diseases of the Liver and Biliary System. Oxford, Blackwell Scientific Publications, 1955, 720 pp.

    Google Scholar 

  17. Steinfeld, J. L., J. D. Davidson, R. S. Gordon, Jr., and F. E. Greene: The mechanism of hypoproteinemia in patients with regional enteritis and ulcerative colitis. Am. J. Med.29: 405, 1960.

    Article  PubMed  CAS  Google Scholar 

  18. Studies of Undernutrition, Wuppertal 1946–1949: Medical Research Council. Special Report Series No. 275, 1951.

Download references

Author information

Author notes

  1. Donald K. Brief M.D. (Formerly Clinical Fellow)

    Present address: American Cancer Society and Senior Resident, Peter Bent Brigham Hospital, Boston, Massachusetts

Authors and Affiliations

  1. From the Department of Surgery, Peter Bent Brigham Hospital, Boston, Massachusetts

    J. Judson McNamara M.D. (Junior Assistant Resident Surgeon) &  Alan B. Gazzaniga M.D. (Junior Assistant Resident Surgeon)

  2. Millburn, New Jersey

    Donald K. Brief M.D. (Formerly Clinical Fellow)

Authors
  1. J. Judson McNamara M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alan B. Gazzaniga M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Donald K. Brief M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

McNamara, J.J., Gazzaniga, A.B. & Brief, D.K. Lethal hepatic failure in ulcerative colitis. Dis Colon Rectum 7, 283–289 (1964). https://doi.org/10.1007/BF02630533

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02630533

Keywords

Search

Navigation