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Ischemic colitis in rats

  • Published:
Diseases of the Colon & Rectum

Abstract

Left-sided ischemic colitis was induced in 44 inbred Male Fischer rats of the same age by a standardized devascularization procedure. Fifteen animals had nothing else done (Group I). Twentynine animals had feces evacuated from the left colon and received an enema just before the procedure; 14 had a sterile-water enema (Group II), and 15 had a 1 per cent hydrocortisone enema (Group III). At sacrifice, 72 hours after the surgical procedure, the mucosal surface grossly involved in ischemic changes was measured. The mean area of ischemic changes in Group I was significantly greater than that of either Group II or Group III (P<.05). The incidence of circumferential changes was highest in Group I and lowest in Group III; the difference between Group I and Group III was marginally significant (P=.06).

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References

  1. Hagihara PF, Ernst CB, Griffen WO Jr. Incidence of ischemic colitis following abdominal aortic reconstruction. Surg Gynecol Obstet 1979;149:571–3.

    PubMed  CAS  Google Scholar 

  2. Matt SG. Local treatment of ulcerative colitis with prednisolone-21-phosphate enemata. Lancet 1960;1:517–9.

    Article  Google Scholar 

  3. Sherman LP, Prem KA, Mensheha NM. Factitial proctitis: a restudy at the University of Minnesota. Dis Colon Rectum 1971;14:281–5.

    Article  PubMed  CAS  Google Scholar 

  4. Truelove SC. Treatment of ulcerative colitis with local hydrocortisone hemisuccinate sodium; a report on a controlled therapeutic trial. Br Med J 1958;2:1072–7.

    PubMed  CAS  Google Scholar 

  5. Watkinson G. Treatment of ulcerative colitis with topical hydrocortisone hemisuccinate sodium: a controlled trial employing restricted sequential analysis. Br Med J 1958;2:1077–82.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Surgical Service, Veterans Administration Medical Center, 40511, Lexington, Kentucky

    Timothy S. Griffen &  Patrick F. Hagihara M.D.

  2. University of Kentucky College of Medicine, Lexington, Kentucky

    Timothy S. Griffen &  Patrick F. Hagihara M.D.

Authors
  1. Timothy S. Griffen
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  2. Patrick F. Hagihara M.D.
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Additional information

Read at the meeting of the American Society of Colon and Rectal Surgeons, Colorado Springs, Colorado, June 7 to 11, 1981.

Supported by the Veterans Administration.

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Griffen, T.S., Hagihara, P.F. Ischemic colitis in rats. Dis Colon Rectum 25, 638–640 (1982). https://doi.org/10.1007/BF02629530

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  • DOI: https://doi.org/10.1007/BF02629530

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