Current Psychosis & Therapeutics Reports

, Volume 1, Issue 2, pp 62–66 | Cite as

Update on the search for genes for bipolar disorder

  • John R. Kelsoe


The past several years have witnessed a series of exciting advances in the genetics of bipolar disorder. Much of this progress has been catalyzed by data and tools emerging from the Human Genome Project. Whereas 4 years ago several chromosomal regions had been identified in linkage studies, now several of the genes in these regions may have been identified. A genetic overlap between bipolar disorder and schizophrenia that was hinted at, now seems certain. Our picture of the genetics of bipolar disorder is also different, with more rather than fewer genes being likely. As daunting as the problem seems to have become, powerful tools have been developed that promise even greater advances. This update reviews this recent progress, and speculates on the future.


Schizophrenia Bipolar Disorder Susceptibility Gene Linkage Study Human Genome Project 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Current Science Inc 2003

Authors and Affiliations

  • John R. Kelsoe
    • 1
  1. 1.Department of Psychiatry, 0603University of California San Diego, and San Diego VA Healthcare SystemLa JollaUSA

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