Summary
Plasma prolactin concentrations were compared in 7 insulin-dependent diabetics (IDD) without clinical evidence of microangiopathy and 6 non-diabetic controls matched for age and sex under basal conditions and in response to an i.v. infusion of arginine. Both groups exhibited a significant elevation in plasma prolactin concentration in response to the arginine infusion. There were no significant differences in basal prolactin concentrations nor in the prolactin response to the arginine infusion when comparing IDD and controls. Insulin-dependent diabetes is therefore not accompanied by a generalized hypothalamic disturbance and it seems likely that prolactin physiology is uninfluenced by the disorder of insulin-dependent diabetes under these circumstances.
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References
Ajlouni K., Sill A. J., Hagen T. C.: Glucoregulation of prolactin secretion — Diabetes25, 351, 1976.
Ragshawe K. D.: Computer controlled automated radioimmunoassay — Lab. Pract.24, 573, 1975.
Brazeau P., Vale W., Burgus R., Ling N., Butcher M., Rivier J., Guillemin R.: Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone — Science179, 77, 1973.
Burday S. Z., Fine P. H., Schalch D. S.: Growth hormone secretion in response to arginine infusion in normal and diabetic subjects: relationship to blood glucose levels — J. Lab. clin. Med.71, 897, 1968.
Copinschi G., L’Hermite M., Vanhaelst L., Leclerq R., Bruno O. D., Goldstein J., Ooms H. A., Robyn C.: Prolactin response to hypoglycaemia — Lancet1, 946, 1973.
Frøland A., Hagen C., Lauritzen E.: Diabetic retinopathy and prolactin — Lancet1, 45, 1977.
Hansen Aa. P.: Abnormal serum growth hormone response to exercise in juvenile diabetics — J. clin. Invest.49, 1467, 1970.
Hanssen K. F., Christensen S. E., Hansen Aa. P., Lundbaek K., Torjesen P. A., Weeke J.: Plasma prolactin in juvenile diabetics. 24-h studies with somatostatin — Diabetologia15, 369, 1978.
Hanssen K. F., Torjesen P. A.: Increased serum prolactin in diabetic ketoacidosis: correlation between serum sodium and serum prolactin concentration — Acta endocr. (Kbh.)85, 372, 1977.
Hanssen K. F., Torjesen P. A., Hansen F. M., Paulsen A. Q., Haug E.: Serum prolactin in juvenile diabetics — In:Bajaj J. S. (Ed.): Current topics in diabetes research. Congr. Int. Diabetes, New Delhi 1976. Excerpta Medica Foundation, Amsterdam, 1976; p. 44, (abstract # 89).
Hunter P. R., Anderson J., Lunn T. A., Horrobin D. F., Boyns A. R., Cole E. N.: Diabetic retinopathy and prolactin — Lancet1, 1237, 1974.
Hwang P., Guyda H., Friesen H. G.: Purification of human prolactin — J. biol. Chem.247, 1955, 1972.
Johansen K., Hansen Aa. P.: Diurnal serum growth hormone levels in poorly and well controlled juvenile diabetics — Diabetes20, 239, 1971.
Knopf R. F., Fajans S. S., Floyd J. C., Pek S., Conn J. W.: Elevated ‘casual’ fasting plasma levels of growth hormone (GH) in patients with diabetic retinopathy (DR) — Diabetes21, 322, 1972.
Landgraf R., Landgraf-Leurs M. C., Weissman A., Horl R., von Werder K., Scriba P. C.: Prolactin: a diabetogenic hormone — Diabetologia13, 99, 1977.
Luft R., Guillemin R.: Growth hormone and diabetes in man. Old concepts — new implications — Diabetes23, 783, 1974.
Noel G. L., Suh H. K., Stone J. G., Frantz A. G.: Human prolactin and growth hormone release during surgery and other conditions of stress — J. clin. Endocr.35, 840, 1972.
Penny R., Blizzard R. M., Davis W. T.: Sequential study of arginine monochloride and normal saline as stimuli to growth hormone release — Metabolism19, 165, 1970.
Schally A. V., Baba Y., Nair R. M. G., Bennett C. D.: The amino acid sequence of a peptide with growth hormone-releasing activity isolated from porcine hypothalamus — J. biol. Chem.246, 6647, 1971.
Takahara J., Arimura A., Schally A. V.: Suppression of prolactin release by a purified porcine PIF preparation and catecholamines infused into a rat hypophyseal portal vessel — Endocrinology95, 462, 1974.
Tashjian A. H., Barowsky N. J., Jensen D. K.: Thyrotrophin releasing hormone: direct evidence for stimulation of prolactin production by pituitary cells in culture — Biochem. biophys. Res. Commun.43, 516, 1971.
Tchobroutsky G., Assad R. G., Rosselin G., Dérot M.: Taux plasmatiques de l’hormone somatotrope chez les diabétiques. Premiers résultats de determinations a jeun, au repos et après administration d’arginine ou d’insuline — Ann. Endocr. (Paris)27, 766, 1966.
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Gray, R.S., Cameron, E.H.D. & Clarke, B.F. Plasma prolactin response to I.V. arginine in insulin-dependent diabetes. Acta diabet. lat 16, 269–273 (1979). https://doi.org/10.1007/BF02629122
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DOI: https://doi.org/10.1007/BF02629122