Summary
Oral cortisone glucose tolerance tests were performed in 66 CS2-exposed workers and in 66 individually matched control subjects. Results indicate a higher and significant (p<0.001) prevalence of latent diabetes in the CS2-exposed group (72.7%) as compared with the control group (16.7%), and the existence of a positive and significant (p<0.001) correlation between blood glucose values and exposure index. Possible mechanisms of action involving zinc metabolism and pyridoxine metabolism are discussed.
References
Audo Giannotti G. B.: Sulle alterazioni endocrine e neurovegetative nel solfocarbonismo sperimentale — Atti XI Congr. Naz. Medicina del Lavoro, Torino 1934.
Austoni M., D’Agnolo B.: Solfocarbonismo cronico e diabete mellito — Minerva med.48, 2500, 1957.
Derot M.: Précis de diabétologie — Masson et Cie Ed., Paris, 1977.
El-Gazzar R., Yassin M. El Sadik, Hussein M.: Changes in zinc and serum proteins due to carbon disulphide exposure — Brit. J. industr. Med.30, 284, 1973.
Fajans S. S., Conn J. W.: An approach to the prediction of diabetes mellitus by modification of the glucose tolerance rest with cortisone — Diabetes3, 296, 1954.
Ferrero G.: Frequenza del diabete mellito nei lavoratori esposti al rischio di intossicazione da solfuro di carbonio — Med. Lavoro60, 38, 1969.
Finulli M., Ghislandi E.: La frequenza del diabete nella intossicazione cronica da solfuro di carbonio — Med. Lavoro,50, 189, 1959.
Goto S., Hotta R.: The medical and hygienic prevention of carbon disulphide poisoning in Japan — In:Brieger H., Teisinger J. (Eds): Toxicology of carbon disulphide. Excerpta Medica Foundation, Amsterdam, 1967; p. 219.
Goto S., Hotta R., Sugimoto K.: Studies on chronic carbon disulphide poisoning — Int. Arch. Arbeitsmed.28, 115, 1971.
Hägglöf B., Hallmans G., Holmgren G., Ludvigsson J.: A prospective study of serum zinc in juvenile onset diabetes mellitus — Acta endocr. (Kbh.)219 (Suppl.) 42, 1978.
Hernberg S., Nordman C. H., Partanen T., Christiansen V., Virkola P.: Blood lipids, glucose tolerance and plasma creatinine in workers exposed to carbon disulphide — Work environ. Hlth8, 11, 1971.
Kotake Y., Sotokawa T., Murakami E., Hisatake A., Abe M., Ikeda Y.: Studies on the xanthurenic acid-insulin complex — J. Biochem. (Tokyo)63, 578, 1968.
Kujalova V.: Carbon disulphide-induced latent impairment of carbohydrate metabolism — 18th Int. Congr. Occupat. Health, Brighton 1975.
Kujalova V., Tintera J.: The effect of carbon disulphide on triptophan metabolism — Med. Lavoro61, 227, 1970.
Lefèbvre P., Luyckx A.: Le prove funzionali in diabetologia — Casa Ed. ‘Il Ponte’, Milano, 1974.
Parmeggiani L., Zanardi S., Sassi C.: Considerazioni su di un caso di solfocarbonismo con glicosuria normoglicemia — Med. Lavoro41, 18, 1950.
Rotelli L., Candura F.: Ricerche sul contenuto in zinco del pancreas umano normale e diabetico — Folia endocr. (Roma)5, 1, 1958.
Scheel L. D.: Experimental carbon disulphide poisoning in rabbits; its mechanism and similarities with human case report — In:Brieger H., Teisinger J. (Eds): Toxicology of carbon disulphide. Excerpta Medica Foundation, Amsterdam, 1967.
Vasak V., Kopecky J.: On the role of pyridoxamine in the mechanism of the toxic action of carbon disulphide — In:Brieger H., Teisinger J. (Eds): Toxicology of carbon disulphide. Excerpta Medica Foundation, Amsterdam, 1967; p. 35.
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Candura, F., Franco, G., Malamani, T. et al. Altered glucose tolerance in carbon disulfiede exposed workers. Acta diabet. lat 16, 259–263 (1979). https://doi.org/10.1007/BF02629120
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DOI: https://doi.org/10.1007/BF02629120