Summary
Glycosylated hemoglobin (Hb) concentrations were measured in 50 patients with clinically significant diabetic neuropathy. There were 24 males and 26 females with a mean age of 58.1 years and a mean duration of diabetes of 8.9 years. The glycosylated Hb concentration was not significantly different in these patients (13.9% ± 2.4 SD) compared with randomly selected diabetic patients matched for age (± 5 years), sex and therapy without clinical evidence of neuropathy (13.6% ± 2.2). There was no significant difference in the duration of diabetes between the two groups. The results would suggest that factors other than the degree of control of diabetes are important in the pathogenesis of diabetic neuropathy.
Similar content being viewed by others
References
Davis R. E., Constable I., Nicol D. J., McCann V. J., Welborn T.: Retinopathy and glycosylated haemoglobin levels in patients with diabetes mellitus - (In press).
Davis R. E., Nicol D. J., McCann V. J., Calder J. S.: Glycosylated haemoglobin in patients with diabetes mellitus - Med. J. Aust.1, 530, 1978.
Ellenberg M.: Diabetic neuropathy: a consideration of factors in onset - Ann. intern. Med.52, 1067, 1960.
Gabbay K. H., Hasty K., Breslow J. L., Ellison C. R., Bunn F. H., Gallop P. M.: Glycosylated hemoglobin and long term blood glucose control in diabetics - J. clin. Endocr.44, 859, 1977.
Gregersen G.: Diabetic neuropathy: influence of age, sex and metabolic control, and duration of diabetes on motor conduction velocity - Neurology (Minneap.)17, 192, 1967.
Koenig R. J., Peterson C. M., Jones R. L., Saunder C., Lehrman M., Cerami A.: Correlation of glucose regulation and hemoglobin A1c in diabetes mellitus - New Engl. J. Med.295, 417, 1976.
Koenig R. J., Peterson C. M., Kilo C., Cerami A., Williamson J. R.: Hemoglobin A1c as an indicator of the degree of glucose intolerance in diabetes- Diabetes25, 230, 1976.
Kynoch P. A. M., Lehmann H.: Rapid estimation (21/2 hours) of glycosylated haemoglobin for routine purposes - Lancet2, 16, 1977.
Malone J. I., Simons C. A., van Cader T. C.: Correlation of HbA1 and diabetic microvascular disease (MVD) - Diabetes27 (Suppl. 2), 434, 1978; abstract # 15.
Mulder D. W., Lambert E. H., Bastron J. A., Sprague R. G.: The neuropathies associated with diabetes mellitus — Neurology (Minneap.)11, 275, 1961.
Pirat J.: Diabetic neuropathy: a metabolic or vascular disease — Diabetes14, 1, 1965.
Trivelli L. A., Ranney H. M., Lai H.-T.: Hemoglobin components in patients with diabetes mellitus — New Engl. J. Med.284, 353, 1971.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
McCann, V.J., Davis, R.E. Glycosylated hemoglobin concentrations in patients with diabetic neuropathy. Acta diabet. lat 16, 205–209 (1979). https://doi.org/10.1007/BF02629113
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02629113