, Volume 9, Issue 1–3, pp 1–5 | Cite as

Transfer factor — Current status and future prospects

  • H. Sherwood Lawrence
  • William Borkowsky


We have detected new clues to the composition and function of “Transfer Factor” using the direct Leucocyte Migration Inhibition (LMI) test as an in vitro assay of Dialysates of Leucocyte Extracts (DLE). This approach has revealed two opposing antigen-specific activities to be present in the same >3500 <12,000 DA dialysis fraction — one activity is possessed of Inducer/Helper function (Inducer Factor). The opposing activity is possessed of Suppressor function (Suppressor Factor).

When non-immune leucocyte populations are cultured with Inducer Factor they acquire the capacity to respond to specific antigen and inhibition of migration occurs. This conversion to reactivity is antigen- specific and dose-dependent. When immune leucocyte populations are cultured with Suppressor Factor their response to specific antigen is blocked and Inhibition of Migration is prevented.


Transfer Factor Delay Type Hypersensitivity Diphtheria Toxoid Dialysis Fraction Leukocyte Migration Inhibition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



dialysable leucocyte extracts


leucocyte migration inhibition test


transfer factor


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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • H. Sherwood Lawrence
    • 1
  • William Borkowsky
    • 1
  1. 1.Infectious Disease and Immunology Division, Departments of Medicine and PediatricsNew York University Medical CenterNew YorkUSA

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