Summary
A syndrome of glucose intolerance associated with hyperinsulinaemia and insulin resistance, skin changes, and mild virilization occurred in two daughters of a first-cousin marriage. The condition is probably inherited as an autosomal recessive trait. It is likely to represent a widespread disturbance in neuro-endocrine control; the primary metabolic error may involve pineal, virilization.
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Barnes, N.D., Palumbo, P.J., Hayles, A.B. et al. Insulin resistance, skin changes, and virilization: A recessively inherited syndrome possibly due to pineal gland dysfunction. Diabetologia 10, 285–289 (1974). https://doi.org/10.1007/BF02627729
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DOI: https://doi.org/10.1007/BF02627729