Summary
When photolyzed in situ for as little as 15 s 2-azido-9-fluorenone oxime causes Type II and Type III transformation in C3H 10T 1/2 CL8 cells. In the yeast strainSaccharomyces cerevisiae D-7, simple reversions and gene conversions occurred and also mitotic crossing over, to a lesser extent, but no mitochondrial “petite” mutants occurred. No mutations or transformation were induced in the dark or by the light itself.
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Supported by NIH Grants CA 17394 and ES02074.
Recipient of a Young Environmental Scientist Award from the National Environmental Health Sciences.
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Dollinger, M.D., Hixon, S.C., Sarrif, A.M. et al. Mutations and cell transformation with 2-azido-9-fluorenone oxime. In Vitro 16, 541–546 (1980). https://doi.org/10.1007/BF02626467
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DOI: https://doi.org/10.1007/BF02626467