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Hyperinsulinism and insulin resistance in polycystic ovarian syndrome: A verification using oral glucose, i.v. glucose and tolbutamide

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Summary

Twenty-six female in patients, aged 14–34 years, suffering from polycystic ovarian syndrome (PCOS) were investigated. Sixteen normal women, matched with patients for age and weight, were used as controls. Both glucose and insulin curves and areas, insulin/glucose area ratio [insulin resistance index (IA/GA)] were studied by oral glucose tolerance test (OGTT), i.v. glucose tolerance test (IVGTT) and tolbutamide test (TT). Plasma insulin and insulin area values of the patients were significantly higher than those of controls. Insulin/glucose area ratios were significantly higher in patients when compared to controls. A correlation was found in some patients (subgroup A) between insulin/glucose area ratio and urinary dehydroepiandrosterone output after the TT. The presence of hyperinsulinism and insulin resistance in our patients suffering from PCOS was confirmed even in the absence of obesity. A relationship between androgens and hyperinsulinism and insulin resistance may thus be confirmed in patients with PCOS.

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Authors and Affiliations

  1. IV Clinica Medica Generale e Terapia Medica, Università di Firenze, Firenze

    Giorgio Cotrozzi, Mauro Matteini, Patrizia Relli & Tiziano Lazzari

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  1. Giorgio Cotrozzi
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  2. Mauro Matteini
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  3. Patrizia Relli
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  4. Tiziano Lazzari
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Cotrozzi, G., Matteini, M., Relli, P. et al. Hyperinsulinism and insulin resistance in polycystic ovarian syndrome: A verification using oral glucose, i.v. glucose and tolbutamide. Acta diabet. lat 20, 135–142 (1983). https://doi.org/10.1007/BF02624914

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  • DOI: https://doi.org/10.1007/BF02624914

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