Summary
Immunodiabetes was produced in young guinea pigs by inoculation of lymph node cells from adult diabetic animals. The ultrastructural alteration of the islets of Langerhans in animals with adoptively transferred diabetes was characterized by a great ultrastructural variability of specific granules and enlarged Golgi bodies in degranulated B-cells. In addition, dilatation of blood capillaries, presence of infiltrates and interaction of infiltrating lymphocytes with B-cells were found in these animals. The nucleolar changes and decreased number of ribosomes on the endoplasmic reticulum were noted in animals with adoptively transferred diabetes as well as in animals treated only with cyclophosphamide.
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Titlbach, M., Smetana, K. & Korčáková, L. Adoptive transfer of immunodiabetes in guinea pig electron microscopy. Acta diabet. lat 12, 114–136 (1975). https://doi.org/10.1007/BF02624731
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DOI: https://doi.org/10.1007/BF02624731