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The role of ranitidine infusion on glucose, insulin and C-peptide serum levels induced by oral glucose tolerance test in healthy subjects

Summary

In 9 healthy subjects we evaluated the effect of a constant ranitidine infusion (100 mg) on glucose (mg/dl), insulin (µU/ml) and C-peptide (ng/ml) serum levels promoted by oral glucose tolerance test (75 g). Ranitidine significantly increased the area under concentration/time curves for glucose and insulin but not that of C-peptide. Our data indicate that ranitidine does not affect pancreatic insulin release nor peripheral glucose utilization and are consistent with the hypothesis that ranitidine influences the hepatic clearance of glucose and insulin both of which undergo high first-pass liver extraction.

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References

  1. Barbara L., Corinaldesi R.: Endocrine effects of H2 receptor antagonist. Proc. Int. Symp. Exp. Clin. Evaluation Anti-ulcer Drugs, Pisa, November 22–23, 1982. S.K.F. Publ., Milano, 1982; p. 121.

    Google Scholar 

  2. Bogues K., Dixon G. T., Fowler P., Jenner W. M., Maconochie J. G., Martin L. E., Wiloughby B. A.: Pharmacokinetics and bioavailability of ranitidine in humans — Brit. J. Pharmacol.73, 275, 1981.

    Google Scholar 

  3. Bratusch-Marrain P. R., Waldhäusl W. K., Gasić S., Hofer A.: Hepatic disposal of biosynthetic human insulin and porcine C-peptide in humans — Metabolism33, 151, 1984.

    PubMed  Article  CAS  Google Scholar 

  4. Buchanan K. D., Spencer C. A., Ardil J., Kennedy T. L.: Altered release of gut and pancreatic hormones by H2-receptor antagonist in treatment of peptic ulcer — Scand. J. Gastroenterol.13, 34, 1978.

    Google Scholar 

  5. Clark A. J. L., Bilous R. W., Keen H.: Ranitidine in insulin-dependent diabetes — Lancetii, 883, 1982.

    Article  Google Scholar 

  6. Delitala G., Devilla L., Pende A., Canessa A.: Effects of the H2-receptor antagonist ranitidine on anterior pituitary hormone secretion in man — Europ. J. clin. Pharmacol.22, 207, 1982.

    Article  CAS  Google Scholar 

  7. Delitala G., Devilla L., Pende A., Lotti G.: Stimulation of prolactin induced by ranitidine, an antagonist of histamine H2-receptors in man — J. endocrinol. Invest.3, 12, 1980.

    Google Scholar 

  8. De Mattia G., Fini M., Laurenti I., Lalli S., Tullo M. G., Ventura C.: Effetti della ranitidina sul metabolismo glucidico — Policlinico, Sez. Prat.89, 644, 1982.

    Google Scholar 

  9. Feeley G., Guy E.: Ranitidine also reduces liver blood flow — Lanceti, 169, 1982.

    Article  Google Scholar 

  10. Garg D. C., Weilder D. J., Jallad N. S., Eshelman F. N.: The effects of rantidine and cimetidine on hepatic blood flow — Clin. Pharmacol. Ther.31, 228, 1982.

    Google Scholar 

  11. Grahmen A., von Bahr C., Lindström B., Rosen A.: Bioavailability and pharmacokinetics of cimetidine — Europ. J. clin. Pharmacol.16, 335, 1979.

    Article  Google Scholar 

  12. Grainger S. L., Marigold J. H., Keeling P. W. N.: Ranitidine and liver blood flow — Lanceti, 236, 1982.

    Google Scholar 

  13. Hittinger R., Knight S. E., Fielding L. P., Lawrence R.: The effect of cimetidine on blood sugar responses to glucose tolerance tests in human volunteers — Brit. J. Surg.65, 356, 1978.

    Google Scholar 

  14. Jefferys D. B., Vale G.A.: Effect of cimetidine on glucose handling — Lanceti, 383, 1978.

    Article  Google Scholar 

  15. Katz A. I., Rubenstein A. H.: Metabolism of proinsulin, insulin and C-peptide in the rat — J. clin. Invest.52, 1113, 1973.

    PubMed  CAS  Article  Google Scholar 

  16. Marchesini G., Bianchi G., Zoli M., Dondi C., Forlani G., Melli A., Bua V., Vannini P., Pisi E.: Plasma amino acid response to protein ingestion in patients with liver cirrhosis — Gastroenterology85, 283, 1983.

    PubMed  CAS  Google Scholar 

  17. McIsaac R. L., Knight S. E., Fielding L. T., Hittinger R.: Cimetidine and pancreatic function — Lanceti, 551, 1978.

    Article  Google Scholar 

  18. Nelis G. F., van de Meene J. G. C.: Comparative effects of cimetidine and ranitidine on prolactin secretion — Postgrad. med. J.56, 478, 1980.

    PubMed  CAS  Article  Google Scholar 

  19. Netti C., Guidobono F., Olgiati V. R., Sibilia V., Pecile A.: Comparison of the effects of histamine H2 receptor antagonists on prolactin secretion. Proc. Int. Symp. Exper. Clin. Evaluation Anti-ulcer Drugs, Pisa, November 22–23, 1982. S.K.F. Publ., Milano, 1982; p. 87.

    Google Scholar 

  20. Ohnisashi K., Saito M., Nakayama T., Tsukamoto T., Sugita S., Terabayashi H., Wada K., Mishima A., Hatano H., Nomura F., Koen H., Okuda K.: Effect of intravenous load of ranitidine on hepatic hemodynamics — Jap. J. Gastroenterol.81, 1426, 1984.

    Google Scholar 

  21. Pomare E. W.: Hyperosmolar non-ketotic diabetes and cimetidine — Lanceti, 1202, 1978.

    Article  Google Scholar 

  22. Scarpignano G., Tirelli F., Starcich R., Bertaccini G.: Insulin response to glucose loading after intravenous cimetidine — Drugs exp. clin. Res.7, 135, 1981.

    Google Scholar 

  23. Sibilia V., Netti C., Guidobono F., Olgiati V. R., Cazzamalli E., Pecile A.: Histamine H2 receptor antagonist and prolactin secretion. Proc. XXI Congr. Soc. Ital. di Farmacologia, Napoli, 2–5 giugno 1982. Idelson Publ., Napoli, 1982; p. 112.

    Google Scholar 

  24. Vernon R. G., Martino R., Unninghake D. B.: Cimetidine blockade of histamine — induced insulin secretion — Clin. Pharmacol. Ther.28, 392, 1980.

    Article  Google Scholar 

  25. Williams R. L.: Drug administration in hepatic disease — New Engl. J. Med.309, 1616, 1983.

    PubMed  CAS  Article  Google Scholar 

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Gentile, S., Marmo, R., Costume, A. et al. The role of ranitidine infusion on glucose, insulin and C-peptide serum levels induced by oral glucose tolerance test in healthy subjects. Acta diabet. lat 23, 165–170 (1986). https://doi.org/10.1007/BF02624676

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  • DOI: https://doi.org/10.1007/BF02624676

Key-words

  • C-peptide
  • Insulin
  • Glycemia
  • Ranitidine