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The role of ranitidine infusion on glucose, insulin and C-peptide serum levels induced by oral glucose tolerance test in healthy subjects

Acta diabetologia latina volume 23, pages 165–170 (1986)Cite this article

Summary

In 9 healthy subjects we evaluated the effect of a constant ranitidine infusion (100 mg) on glucose (mg/dl), insulin (µU/ml) and C-peptide (ng/ml) serum levels promoted by oral glucose tolerance test (75 g). Ranitidine significantly increased the area under concentration/time curves for glucose and insulin but not that of C-peptide. Our data indicate that ranitidine does not affect pancreatic insulin release nor peripheral glucose utilization and are consistent with the hypothesis that ranitidine influences the hepatic clearance of glucose and insulin both of which undergo high first-pass liver extraction.

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Authors and Affiliations

  1. Istituto di Semeiotica Medica I Facoltà di Medicina e Chirurgia II Policlinico, Via S. Pansini 5, 80131, Napoli, Italy

    Sandro Gentile, Riccardo Marmo, Andrea Costume, Cosimo Orlando, Mario Porcellini & Mario Coltorti

  2. Ospedale Ascalesi, Napoli

    Rita D’Alessandro & Giuseppe De Bellis

  3. Associazione Italiana Diabete, Napoli

    Sandro Gentile, Riccardo Marmo, Andrea Costume, Cosimo Orlando, Mario Porcellini & Mario Coltorti

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  1. Sandro Gentile
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  2. Riccardo Marmo
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  3. Andrea Costume
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  4. Cosimo Orlando
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  5. Rita D’Alessandro
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  6. Giuseppe De Bellis
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  7. Mario Porcellini
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  8. Mario Coltorti
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Gentile, S., Marmo, R., Costume, A. et al. The role of ranitidine infusion on glucose, insulin and C-peptide serum levels induced by oral glucose tolerance test in healthy subjects. Acta diabet. lat 23, 165–170 (1986). https://doi.org/10.1007/BF02624676

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  • DOI: https://doi.org/10.1007/BF02624676

Key-words

  • C-peptide
  • Insulin
  • Glycemia
  • Ranitidine