Skip to main content

The role of junctional communication in animal tissues

Summary

Permeable intercellular junctions are a common feature of most animal tissues. These junctions allow the free exchange of small ions and molecules between all the cells in coupled populations. Such limited syncytial interaction contributes to the integration of individual cells into organized tissues.

This is a preview of subscription content, access via your institution.

References

  1. Furshpan, E. J.; Potter, D. D. Transmission at giant motor synapses of the crayfish. J. Physiol. 143: 289–325; 1959.

    Google Scholar 

  2. Loewenstein, W. R. Permeability of membrane junctions. Ann. N.Y. Acad. Sci. 137: 441–472; 1966.

    PubMed  Article  CAS  Google Scholar 

  3. Furshpan, E. J.; Potter, D. D. Low resistance junctions between cells in embryos and in tissue culture. Curr. Top. Dev. Biol. 3: 95–127; 1968.

    PubMed  CAS  Article  Google Scholar 

  4. Loewenstein, W. R. Permeable junctions. Cold Spring Harbor Symp. Quant. Biol. 40: 49–63; 1976.

    PubMed  CAS  Google Scholar 

  5. Subak-Sharpe, J. H.; Bürk, R. R.; Pitts, J. D. Metabolic co-operation by cell-cell transfer between genetically different mammalian cells in tissue culture (abstr.). Heredity 21: 342; 1966.

    Google Scholar 

  6. Bürk, R. R.; Pitts, J. D.; Subak-Sharpe, J. H. Exchange between hamster cells in tissue culture. Exp. Cell Res. 53: 297–301; 1968.

    PubMed  Article  Google Scholar 

  7. Subak-Sharpe, J. H.; Bürk, R. R.; Pitts, J. D. Metabolic co-operation between biochemically marked mammalian cells in tissue culture. J. Cell Sci. 4: 353–367; 1969.

    PubMed  CAS  Google Scholar 

  8. Cox, R. R.; Krauss, M. R.; Balis, M. E.; Dancis, J. Evidence for transfer of enzyme product as the basis of metabolic cooperation between tissue culture fibroblasts. Proc. Natl. Acad. Sci. USA 67: 1573–1579; 1970.

    PubMed  Article  CAS  Google Scholar 

  9. Pitts, J. D. Molecular exchange and growth control in tissue culture. Growth control in cell cultures. Ciba Found. Symp. 89–105; 1971.

  10. Pitts, J. D.; Simms, J. W. Permeability of junctions between animal cells: intercellular transfer of nucleotides but not macromolecules. Exp. Cell Res. 104: 153–163; 1977.

    PubMed  Article  CAS  Google Scholar 

  11. Lawrence, T. S.; Beers, W. H.; Gilula, N. B. Hormonal stimulation and cell communication in cocultures. Nature 272: 501–506; 1978.

    PubMed  Article  CAS  Google Scholar 

  12. Sheridan, J. D.; Finbow, M. E.; Pitts, J. D. Metabolic interactions between animal cells through permeable intercellular junctions. Exp. Cell Res. 123: 111–119; 1979.

    PubMed  Article  CAS  Google Scholar 

  13. Moor, R. M.; Smith, M. W.; Dawson, R. M. C. Measurement of intercellular coupling between oocytes and cumulus cells using intracellular markers. Exp. Cell Res. 126: 15–29; 1980.

    PubMed  Article  CAS  Google Scholar 

  14. Pitts, J. D.; Shaw, K. D. The detection of junctional communication in culture. Cell Biol. Int. Rep. 4: 758; 1980.

    Article  CAS  Google Scholar 

  15. Finbow, M. E.; Pitts, J. D. Permeability of junctions between animal cells; transfer of metabolites and a vitamin derived cofactor. Exp. Cell Res., submitted for publication.

  16. Gilula, N. B.; Reeves, D. R.; Steinbach, A. Metabolic coupling, ionic coupling and cell contacts. Nature 235: 262–265; 1973.

    Article  Google Scholar 

  17. Caspar, D. L. D.; Goodenough, D. A.; Makowski, L.; Phillips, W. C. Gap junction structures. J. Cell Biol. 74: 605–628; 1977.

    PubMed  Article  CAS  Google Scholar 

  18. Makowski, L.; Caspar, D. L. D.; Phillips, W. C.; Goodenough, D. A. Gap junction structures. Analysis of X-ray diffraction data. J. Cell Biol. 74: 629–645; 1977.

    PubMed  Article  CAS  Google Scholar 

  19. Zampighi, G.; Unwin, P. N. T. Two forms of isolated gap junctions. J. Mol. Biol. 135: 451–464; 1979.

    PubMed  Article  CAS  Google Scholar 

  20. Unwin, P. N. T.; Zampighi, G. Structure of the junctions between communicating cells. Nature 283: 545–549; 1980.

    PubMed  Article  CAS  Google Scholar 

  21. Loewenstein, W. R. Permeability of the junctional membrane channel. Brinkley, B. R.; Porter, K. R. eds. International cell biology. New York: Rockefeller University Press; 1977; 70–82.

    Google Scholar 

  22. Flagg-Newton, J. L.; Simpson, I.; Loewenstein, W. R. Permeability of the cell-cell membrane channels in mammalian cell junctions. Science 205: 404–409; 1979.

    PubMed  Article  CAS  Google Scholar 

  23. Tangl, E. Ueber offene Communicatione zwischen den Zellen des Endosperms einiger Samen. Jb. Wiss. Bot. 12: 170–190; 1879.

    Google Scholar 

  24. Carr, D. J. Historical perspectives on plasmodesmata. Gunning, B. E. S.; Robards, A. W. eds. Intercellular communication in plants: studies on plasmodesmata. Berlin: Springer-Verlag: 1976: 291–295.

    Google Scholar 

  25. Flemming, W. Leipzig: Kern and Zellteilung; 1882.

  26. Retzius, G. Die Intercellularbrücken des Eierstockeiesund der Follikelzellen. Verh. Anat. Ges.: 1889.

  27. Strasburger, E. Ueber Plasmaverbindungen pflanzlicher Zellen. Jb. Wiss. Bot. 36: 493–610; 1901.

    Google Scholar 

  28. Münch, E. Die Stoffbewegung in er Pflanze. Jena Gustav Fischer; 1930.

    Google Scholar 

  29. Gunning, B. E. S.; Robards, A. W. Current knowledge and outstanding problems. Gunning, B. E. S.; Robards, A. W. eds. Intercellular communication in plants: studies on plasmodesmata. Berlin: Springer Verlag; 1976: 297–311.

    Google Scholar 

  30. Ley, K. D. Detection of G1 proteins in cells synchronized by isoleucine starvation or mitotic selection. J. Cell Biol. 66: 95–105; 1975.

    PubMed  Article  CAS  Google Scholar 

  31. Heslop-Harrison, J. Differentiation. Ann. Rev. Plant Physiol. 18: 325–348; 1967.

    Article  Google Scholar 

  32. Iwatsuki, N.; Petersen, O. H. Electrical coupling and uncoupling in pancreatic acinar cells. J. Cell Biol. 79: 533–545; 1978.

    PubMed  Article  CAS  Google Scholar 

  33. Graf, J.; Petersen, O. H. Cell membrane potential and resistance in liver. J. Physiol. 284: 105–126; 1978.

    PubMed  CAS  Google Scholar 

  34. Caveney, S. Intercellular communication in a positional field; movement of small ions between insect epidermal cells. Dev. Biol. 40: 311–322; 1974.

    PubMed  Article  CAS  Google Scholar 

  35. Lawrence, P. A.; Green, S. M. The anatomy of a compartment border. J. Cell Biol. 65: 373–382; 1975.

    Article  Google Scholar 

  36. Daniel, E. E.; Daniel, V. P.; Duchon, G.; Garfield, R. E. Is the nexus necessary for cell-to-cell coupling of smooth muscle? J. Membr. Biol. 28: 207–239; 1976.

    PubMed  Article  CAS  Google Scholar 

  37. Lo, C. W.; Gilula, N. B. Gap junctional communication in the pre-implantation mouse embryo. Cell 18: 399–410; 1979.

    PubMed  Article  CAS  Google Scholar 

  38. Lo, C. W.; Gilula, N. B. Gap junctional communication in the post-implantation mouse embryo. Cell 18: 411–422; 1979.

    PubMed  Article  CAS  Google Scholar 

  39. Gardner, R. L.; Rossant, J. Determination during embryogenesis. Embryogenesis in mammals. Ciba Found. Symp. 40: 5–25; 1976.

    Google Scholar 

  40. Slack, C.; Palmer, J. P. The permeability of intercellular junctions in the early embryo ofXenopus laevis studied with fluorescent tracer. Exp. Cell Res. 55: 416–431; 1969.

    PubMed  Article  CAS  Google Scholar 

  41. Pitts, J. D.; Bürk, R. R. Specificity of junctional communication between animal cells. Nature 264: 762–764; 1976.

    PubMed  Article  CAS  Google Scholar 

  42. Fentiman, I.; Taylor-Papadimitriou, J.; Stocker, M. Selective contact-dependent cell communication. Nature 264: 760–762; 1976.

    PubMed  Article  CAS  Google Scholar 

  43. Gaunt, S.; Subak-Sharpe, J. H. Selectivity in metabolic co-operation between cultured mammalian cells. Exp. Cell res. 120: 307–320; 1979.

    PubMed  Article  CAS  Google Scholar 

  44. Hunter, G. K.; Pitts, J. D. Specificity of junction formation by mammalian cells. Exp. Cell Res., submitted for publication.

  45. Moor, R. M.; Smith, M. W.; Amino acid transport in mammalian oocytes. Exp. Cell Res. 119: 333–341; 1979.

    PubMed  Article  CAS  Google Scholar 

  46. Anderson, E.; Albertini, D. F. Gap junctions between the oocyte and the companion follicle cells in the mammalian ovary. J. Cell Biol. 71: 680–686; 1976.

    PubMed  Article  CAS  Google Scholar 

  47. Gilula, N. B.; Epstein, M. L.; Beers, W. H. Cell-to-cell communication and ovulation. J. Cell Biol. 78: 58–75; 1978.

    PubMed  Article  CAS  Google Scholar 

  48. Pitot, H. C.; Peraino, C.; Morse, P. A.; van Potter, R. Hepatomas in tissue culture compared with adapting liverin vivo. J. Natl. Cancer Inst. Monogr. 13: 229–245; 1964.

    CAS  Google Scholar 

  49. Goldfarb, P. S. G.; Slack, C.; Subak-Sharpe, J. H.; Wright, E. D. Metabolic cooperation between cells in tissue culture. Symp. Soc. Exp. Biol. 28: 463–484; 1974.

    PubMed  CAS  Google Scholar 

  50. Kohen, E.; Kohen, C. Rapid automated multichannel microspectrofluorimetry. Exp. Cell Res. 107: 261–268; 1977.

    PubMed  Article  CAS  Google Scholar 

  51. Zoref, E.; Vries, A. de; Sperling, O. Metabolic cooperation between human fibroblasts with normal and with mutant superactive phosphoribosyl pyrophosphate synthetase. Nature 260: 786–788; 1976.

    Article  CAS  Google Scholar 

  52. Cosaro, C. M.; Migeon, B. R. Contact-mediated communication of ouabain resistance in mammalian cells in culture. Nature 268: 737–739; 1977.

    Article  Google Scholar 

  53. Ledbetter, M. L. S.; Lubin, M. Transfer of potassium. A new measure of cell-cell coupling. J. Cell Biol. 80: 166–182; 1979.

    Article  Google Scholar 

  54. Pitts, J. D.; Finbow, M. E. Junctional permeability and its consequences. DeMello, W. C. ed. Intercellular communication. New York: Plenum; 1977; 61–86.

    Google Scholar 

  55. Sheridan, J. D. Cell coupling and cell communication during embryogenesis. Poste, G.; Nicholson, G. L., eds. The cell surface in animal embryogenesis and development. New York: Elsevier-North Holland; 1977: 409–447.

    Google Scholar 

  56. Griepp, E. B.; Revel, J.-P. Gap junctions and development. DeMello, W. C. ed. Intercellular communication. New York: Plenum; 1977: 1–32.

    Google Scholar 

  57. Loewenstein, W. R. Junctional intercellular communication and the control of growth. Biochim. Biophys. Acta. 560: 1–65; 1979.

    PubMed  CAS  Google Scholar 

  58. Wolpert, L. Gap junctions; channels of communication in development. Feldman, J.; Gilula, N. B.; Pitts, J. D. eds. Intercellular junctions and synapses. London: Chapman and Hall; 1978: 81–96.

    Google Scholar 

Download references

Author information

Affiliations

Authors

Additional information

This symposium was supported in part by Contract 263-MD-025754 from the National Cancer Institute and the Fogarty International Center.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Pitts, J.D. The role of junctional communication in animal tissues. In Vitro 16, 1049–1056 (1980). https://doi.org/10.1007/BF02619255

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02619255

Key words

  • gap junctions
  • junctional communication
  • tissue organization