Summary
The fine structure of clone 929-L cells was compared with that of the variant, LE, which is resistant to human serum containing naturally occurring cytotoxic antibodies. Three differences between the two cell types were consistently found.
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1.
The nuclear outline of LE cells was markedly more irregular than that of L cells.
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2.
LE cells had about 20% more mitochondria per cell, as estimated by counts made on sections of single cells.
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3.
Virus-like particles, which were consistently present in cultures of both cell types, were present in large numbers at the surfaces of LE cells whereas these particles were predominantly intracellular in L cells.
The possible relationship of the differences in distribution of the particles to known differences in the immunological properties of the two cell types is discussed.
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These studies were supported by Grants MT-1024 and MA-2570 from the Medical Research Council of Canada.
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Tanaka, Y., Newstead, J. & Fedoroff, S. Comparative studies on the fine structure of clone 929-L cells and their variant, LE cells. In Vitro 7, 6–12 (1971). https://doi.org/10.1007/BF02618998
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DOI: https://doi.org/10.1007/BF02618998