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Sensitivity of human pancreatic carcinoma cell line (MIA PaCa-2) to Bisantrene and Theprubicin in vitro

In Vitro volume 20, pages 685–691 (1984)Cite this article

Summary

We tested the effect of Bisantrene (BS) and Theprubicin (THP-ADR) on cell growth of a human pancreatic carcinoma cell line (MIA PaCa-2). After 1 h exposure ID50 of BS or THP-ADR was 3×10−7 and 5×10−8 M, respectively. Increasing the exposure time from 1 h to continuous exposure for 5d resulted in 11-fold decrease in ID50 for BS and a 6-fold decrease for THP-ADR. Both drugs inhibited [14C]thymidine incorporation to the same extent and caused an accumulation of cells into G2+M phase of the cell cycle.

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Affiliations

  1. Department of Medicine, Biochemistry and Oncology, University of Miami School of Medicine, 33101, Miami, Florida

    George Fountzilas, Lori O. Lim & Adel A. Yunis

Authors
  1. George Fountzilas
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  2. Lori O. Lim
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  3. Adel A. Yunis
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Additional information

This work is supported by a gift, from Mr. Issam Fares and U.S. Public Health Service Grants AM 07114 and CA 19182.

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Fountzilas, G., Lim, L.O. & Yunis, A.A. Sensitivity of human pancreatic carcinoma cell line (MIA PaCa-2) to Bisantrene and Theprubicin in vitro. In Vitro 20, 685–691 (1984). https://doi.org/10.1007/BF02618873

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  • DOI: https://doi.org/10.1007/BF02618873

Key words

  • pancreatic cancer
  • Theprubicin
  • Bisantrene
  • pancreatic carcinoma MIA PaCa-2 cell line