Summary
In vitro exposures of mass cultures and clones of human diploid fibroblastlike cells to erythromycin, in concentrations of 50 to 400 μg/ml, result in increasing degrees of growth inhibition and augmented cell volume, with a shift toward larger proportions of cells of the epithelioid type and fewer of the fibroblast type. These alterations were reversed upon subculture in the absence of the antibiotic.
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This research was supported by National Institutes of Health grants AG 00257 and RR 08139 (Division of Research Resources and National Institute on Aging) and National Science Foundation grant PCM-8003728.
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Martinez, A.O., Norwood, T.H. & Martin, G.M. Growth inhibition and morphologic modulation of human fibroblastlike cells by erythromycin. In Vitro 17, 979–984 (1981). https://doi.org/10.1007/BF02618422
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DOI: https://doi.org/10.1007/BF02618422