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Characterization of newly established human osteosarcoma cell line, LM-1

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Summary

The characteristics of Cell Line LM-1, established from a human osteosarcoma, have been studied extensively. The cell produced both bone-specific and placental-like alkaline phosphatases when treated with hydrocortisone 21-phosphate; they had specific membrane antigens that reacted with sera from osteosarcoma patients. Injection of LM-1 cells into newborn hamsters treated with antilymphocyte serum produced nodular tumors. The characteristics of LM-1 suggest that this tumor cell line has unique features that may be useful in a variety of studies of human and animal osteosarcoma.

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Authors and Affiliations

  1. Department of Basic and Clinical Immunology and Microbiology, Medical University of South Carolina, 29403, Charleston, South Carolina

    Kwong-Y. Tsang & H. Hugh Fudenberg

  2. Department of Pediatrics, Medical University of South Carolina, 29403, Charleston, South Carolina

    G. Shashidhar Pai

Authors
  1. Kwong-Y. Tsang
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  2. G. Shashidhar Pai
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  3. H. Hugh Fudenberg
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Additional information

This research is supported in part by USPHS Grants HD-09938 and CA-25746.

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Tsang, KY., Pai, G.S. & Fudenberg, H.H. Characterization of newly established human osteosarcoma cell line, LM-1. In Vitro 17, 308–314 (1981). https://doi.org/10.1007/BF02618142

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  • DOI: https://doi.org/10.1007/BF02618142

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