Summary
A cell line and subline with epithelial characteristics were established from mouse mammary hyperplastic alveolar nodules (HAN). The cells do not grow in suspension cultures in vitro or form tumors in vivo. The cells do produce significant amounts of C-type and A-type virus and low amounts of plasminogen activator.
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References
DeOme, K. B., L. J. Faulkin, H. A. Bern, and P. B. Blair. 1959. Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice. Cancer Res. 19: 515–520.
Medina, D. 1973. Preneoplastic lesions in mouse mammary tumorigenesis. Methods Cancer Res. 7:3–53.
Slemmer, G. 1972. Host responses to premalignant mammary tissue. J. Natl. Cancer Inst. Monograph 35: 57–71.
Owens, R. B. 1974. Glandular epithelial cells from mice: a method of selective cultivation. J. Natl. Cancer Inst. 52: 1375–1378.
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This work was supported by ACS Postdoctoral Fellowship PF-1473, and Grant 5-ROI-CA-16392-05 and Contract NO1-CB-63986 from the National Institutes of Health.
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Anderson, L.W., Danielson, K.G. & Hosick, H.L. Epithelial cell line and subline established from premalignant mouse mammary tissue. In Vitro 15, 841–843 (1979). https://doi.org/10.1007/BF02618037
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DOI: https://doi.org/10.1007/BF02618037