Skip to main content

Advertisement

SpringerLink
Log in

Intralymphatic 5-Fluorouracil and radioactive gold as an adjuvant to surgical operation for colorectal carcinoma

  • Published:
Diseases of the Colon & Rectum

Summary

Administration of 5-FU and198Au directly to regional lymphatics was utilized as an adjuvant to surgical operation in patients with potentially curable carcinomas of the colon and rectum. The five-year survival rates in 107 patients receiving 5-FU and 58 patients receiving198Au were compared with that in 136 patients treated by surgical resection alone.

In 5-FU-treated patients, either with or without cancer metastatic to the regional lymph nodes, there was no improvement in survival over that in the control group. Similarly,198Au had no effect on the survival rate of patients without tumor cells in the regional nodes. However, 53 per cent of198Au-treated patients with metastases to lymph nodes were alive after five years, compared with 24.4 per cent of the comparable control group.

These results suggest that regional intralymphatic administration of Radiotherapeutic agents as an adjuvant to surgery offers some promise in the treatment of colorectal carcinoma and that continued evaluation is justified.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ackerman, L. V., and J. A. del Regato: Cancer: Diagnosis, Treatment, and Prognosis. Ed. 3. St. Louis, C. V. Mosby Company, 1962, 1296 pp.

    Google Scholar 

  2. Ariel, I. M., M. I. Resnick, and D. Galey: The intralymphatic administration of radioactive isotopes and cancer chemotherapeutic drugs. Surgery.55: 355, 1964.

    PubMed  CAS  Google Scholar 

  3. Copeland, E. M., L. D. Miller, and R. S. Jones: Prognostic factors in carcinoma of the colon and rectum. Amer. J. Surg.116: 875, 1968.

    Article  PubMed  CAS  Google Scholar 

  4. Dukes, C. E.: The surgical pathology of tumours of the colon. Med. Press.226: 512, 1951.

    PubMed  CAS  Google Scholar 

  5. Eastern Cooperative Group in Solid Tumor Chemotherapy: Comparison of antimetabolites in the treatment of breast and colon cancer. J.A.M.A.200: 770, 1967.

    Article  Google Scholar 

  6. Fischer, H. W.: Intralymphatic introduction of radioactive colloids into the lymph nodes. Radiology.79: 297, 1962.

    PubMed  CAS  Google Scholar 

  7. Gilchrist, R. K.: Lymphatic spread of carcinoma of the colon. Dis. Colon Rectum.2: 69, 1959.

    Article  PubMed  CAS  Google Scholar 

  8. Gilchrist, R. K.: Rectum and Colon Cancer. World Wide Abstr. Gen. Med.4: 34, 1961.

    PubMed  CAS  Google Scholar 

  9. James, A. G.: Cancer Prognosis Manual. New York, American Cancer Society, Inc., 1966, 83 pp.

    Google Scholar 

  10. Kinmonth, J. B.: Lymphangiography in man: A method of outlining lymphatic trunks at operation. Clin. Sci.11: 13, 1952.

    PubMed  CAS  Google Scholar 

  11. Liebner, E. J., R. E. Haas, and E. P. Leroy: Experimental therapeutic intralymphatic studies. Cancer.18: 827, 1965.

    Article  PubMed  CAS  Google Scholar 

  12. Rousselot, L. M., D. R. Cole, C. E. Grossi, A. J. Conte, E. M. Gonzalez, and B. S. Pasternack: A five year progress report on the effectiveness of intraluminal chemotherapy (5-fluorouracil) adjuvant to surgery for colorectal cancer. Amer. J. Surg.115: 140, 1968.

    Article  PubMed  CAS  Google Scholar 

  13. Schwartz, S. I., R. H. Greenlaw, C. Rob, and P. Rubin: Intralymphatic injection of radioactive gold: A preliminary experimental report. Cancer.15: 623, 1962.

    Article  PubMed  CAS  Google Scholar 

  14. Seaman, W. B., and W. E. Powers: Studies on the distribution of radioactive colloidal gold in regional lymph nodes containing cancer. Cancer.8: 1044, 1955.

    Article  PubMed  CAS  Google Scholar 

  15. Seitzman, D. M., F. A. Halaby, P. Flanagan, R. Wright, and J. H. Freeman: Intralymphatic radioisotope therapy. Surg. Gynec. Obstet.118: 52, 1964.

    PubMed  CAS  Google Scholar 

  16. Turnbull, R. B., Jr., K. Kyle, F. R. Watson, and J. Spratt: Cancer of the colon: The influence of theno-touch isolation technic on survival rates. Ann. Surg.166: 420, 1967.

    Article  PubMed  Google Scholar 

  17. Wallace, S., L. Jackson, and R. R. Greening: Clinical application of lymphangiography. Amer. J. Roentgenol.88: 97, 1962.

    PubMed  CAS  Google Scholar 

  18. Zeidman, I., B. E. Copeland, and S. Warren: Experimental studies on the spread of cancer in the lymphatic system. II. Absence of a lymphatic supply in carcinoma. Cancer.8: 123, 1955.

    Article  PubMed  CAS  Google Scholar 

  19. Zubrod, C. G.: Effects of 5-fluorouracil and 5-fluorodeoxyuridine on gastrointestinal cancer. J.A.M.A.178: 832, 1961.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. From the Department of Surgery and Division of Radiation Therapy, Department of Radiology, University of Rochester Medical Center, Rochester, New York

    James T. Adams M.D., Seymour I. Schwartz M.D., Phillip Rubin M.D. & Charles G. Rob M.D.

Authors
  1. James T. Adams M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Seymour I. Schwartz M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Phillip Rubin M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Charles G. Rob M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Adams, J.T., Schwartz, S.I., Rubin, P. et al. Intralymphatic 5-Fluorouracil and radioactive gold as an adjuvant to surgical operation for colorectal carcinoma. Dis Colon Rectum 13, 201–206 (1970). https://doi.org/10.1007/BF02617208

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02617208

Keywords

Search

Navigation