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Evaluation of 3:2′-dimethyl-4-aminobiphenyl hydrochloride as a carcinogenic agent in rats

  • Published:
Diseases of the Colon & Rectum

Conclusions

The results of this experiment indicate that 3:2′-dimethyl-4-aminobiphenyl hydrochloride is unsuitable as a carcinogenic agent.

Possibly, future experiments with the free amine form in the pure state should be attempted, perhaps utilizing radioactive tagging of the carcinogen to determine the carcinogenic metabolite. Periodic chemical and biologic assay should be made of a carcinogenic agent to determine the presence of contaminants.

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References

  1. Cleveland, J. C., and J. W. Cole: Identification of the route of action of the colonic carcinogen 3:2′-dimethyl-4-aminodiphenyl. Surgical Forum.17: 314, 1966.

    PubMed  CAS  Google Scholar 

  2. Spjut, H. J., and J. S. Spratt, Jr.: Endemic and morphologic similarities existing between spontaneous colonic neoplasms in man and 3:2′-dimethyl-4-aminobiphenyl induced colonic neoplasms in rats. Ann. Surg.161: 309, 1965.

    Article  PubMed  CAS  Google Scholar 

  3. Walpole, A. L., M. H. C. Williams, and D. C. Roberts: The carcinogenic action of 4-aminodiphenyl and 3:2′-dimethyl-4-aminodiphenyl. Brit. J. Indust. Med.9: 255, 1952.

    CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. From the Department of Surgery, St. Vincent’s Hospital and Medical Center of New York, New York, New York

    T. P. Higgins M.D., C. E. Grossi M.D., A. J. Conte M.D. & L. M. Rousselot M.D.

Authors
  1. T. P. Higgins M.D.
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  2. C. E. Grossi M.D.
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  3. A. J. Conte M.D.
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  4. L. M. Rousselot M.D.
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Additional information

American Cancer Society Fellow.

Deputy Assistant Secretary of Defense (Health and Medicine), Washington, D. C.

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Higgins, T.P., Grossi, C.E., Conte, A.J. et al. Evaluation of 3:2′-dimethyl-4-aminobiphenyl hydrochloride as a carcinogenic agent in rats. Dis Colon Rectum 11, 365–366 (1968). https://doi.org/10.1007/BF02616991

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  • DOI: https://doi.org/10.1007/BF02616991

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