Skip to main content

Advertisement

SpringerLink
Log in

Carcinoma of colon complicating ulcerative colitis

Report of ten cases

  • Published:
Diseases of the Colon & Rectum

Summary and Conclusions

There were ten additional patients in whom ulcerative colitis was complicated by cancer of the colon. A total of 33 patients with carcinoma of the colon among approximately 1,200 patients with ulcerative colitis have been identified. Seven of the ten are dead. The average age when cancer appeared was 44 years and malignancy was diagnosed after an average duration of ulcerative colitis of 17 years. The distribution of carcinoma was more diffuse throughout the colon in ulcerative colitis than that in the case ofordinary cancer of the large bowel. The neoplasia frequently was multifocal, presented variable histopathologic characteristics, and involved new sites in the colon after removal of the initial tumor. Involvement of lymph nodes was present in most cases, but it did not exclude the possibility of prolonged periods of survival.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ackerman, L. V.: Personal communication to the authors.

  2. Banks, B. M., B. I. Korelitz and L. Zetzel: The course of nonspecific ulcerative colitis: Review of 20 years’ experience and late results. Gastroenterology.32: 983, 1957.

    PubMed  CAS  Google Scholar 

  3. Bargen, J. A. and R. P. Gage: Carcinoma and ulcerative colitis: Prognosis. Gastroenterology.39: 385, 1960.

    PubMed  CAS  Google Scholar 

  4. Brooke, B. N.: Malignant change in ulcerative colitis. Dis. Colon & Rectum.4: 393, 1961.

    Article  CAS  Google Scholar 

  5. Dawson, J. M. and J. Pryse-Davies: Ulcerative colitis and carcinoma coli. Lancet.1: 1048, 1959.

    Article  Google Scholar 

  6. Dennis, C. and K. E. Karlson: Cancer risk in ulcerative colitis: Formidability per patient-year of late disease. Surgery.50: 568, 1961.

    Google Scholar 

  7. Fraisse, H., E. Corajod and J. Meley: Trois cas de dégénérescence néoplaslque de polypes du côlon. Arch. mal. app. digest.46: 1043, 1957.

    CAS  Google Scholar 

  8. Galambos, J. T., B. W. Massey, I. Klayman and J. B. Kirsner: Exfoliative cytology in chronic ulcerative colitis. Cancer.9: 152, 1956.

    Article  PubMed  CAS  Google Scholar 

  9. Ginzburg, L. and D. A. Dreiling: Successive independent (metachronous) carcinomas of the colon. Ann. Surg.143: 117, 1956.

    Article  PubMed  CAS  Google Scholar 

  10. Goldgraber, M. B., E. M. Humphreys, J. B. Kirsner and W. L. Palmer: Carcinoma and ulcerative colitis: A clinical-pathologic study. I. Cancer deaths. Gastroenterology.34: 809, 1958.

    PubMed  CAS  Google Scholar 

  11. Goldgraber, M. B., E. M. Humphreys, J. B. Kirsner and W. L. Palmer: Carcinoma and ulcerative colitis: A clinical-pathologic study. II. Statistical analysis. Gastroenterology.34: 840, 1958.

    PubMed  CAS  Google Scholar 

  12. Goldgraber, M. B., E. M. Humphreys, J. B. Kirsner and W. L. Palmer: Carcinoma and ulcerative colitis: A clinical-pathologic study. III. Survivors. Gastroenterology.36: 613, 1959.

    PubMed  CAS  Google Scholar 

  13. Lumb, G. and R. H. B. Protheroe: Ulcerative colitis: A pathologic study of 152 surgical specimens. Gastroenterology.34: 381, 1958.

    PubMed  CAS  Google Scholar 

  14. Maratka, Z. and J. Krumlova: Ulcerative colitis and colon cancer: Case report. Cesk. gastroent. vyz.15: 612, 1961.

    PubMed  CAS  Google Scholar 

  15. Michener, W. M., R. P. Gage, W. G. Sauer and G. B. Stickler: The prognosis of chronic ulcerative colitis in children. New England J. Med.265: 1075, 1961.

    Article  CAS  Google Scholar 

  16. Moertel, C. G., J. A. Bargen and M. B. Dockerty: Multiple carcinomas of the large intestine: A review of the literature and a study of 261 cases. Gastroenterology.34: 85, 1958.

    PubMed  CAS  Google Scholar 

  17. Rosenqvist, H., H. Öhrling, R. Lagercrantz and N. Edling: Ulcerative colitis and carcinoma coli. Lancet.1: 906, 1959.

    Article  CAS  PubMed  Google Scholar 

  18. Russell, I. S. and E. S. R. Hughes: Carcinoma of the colon complicating ulcerative colitis. Australian & New Zealand J. Surg.30: 306, 1961.

    CAS  Google Scholar 

  19. Svartz, N. and T. Gillnäs: In which phase of ulcerative colitis does colonic cancer occur? Am. J. Digest. Dis.3: 537, 1958.

    Article  PubMed  CAS  Google Scholar 

  20. Thompson, J. E.: Ulcerative colitis. South. M. J.54: 801, 1961.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. From the Department of Medicine, University of Chicago, Chicago, Illinois

    Moshe B. Goldgraber M.D. & Joseph B. Kirsner M.D.

Authors
  1. Moshe B. Goldgraber M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Joseph B. Kirsner M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This study was supported in part by grants from the National Cancer Institute of the National Institutes of Health.

About this article

Cite this article

Goldgraber, M.B., Kirsner, J.B. Carcinoma of colon complicating ulcerative colitis. Dis Colon Rectum 7, 336–344 (1964). https://doi.org/10.1007/BF02616837

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02616837

Keywords

Search

Navigation