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Production of erythropoietin in vitro: A review

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Summary

The in vitro production of the important regulatory of erythropoiesis, erythropoietin (Epo), is reviewed. It is concluded that it is possible to produce almost routinely small quantities of Epo in tissue culture. Although such procedures offer the potential to provide large quantities of the hormone for clinical use, the optimum culture conditions and mechanisms for triggering Epo production have yet to be resolved.

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Authors and Affiliations

  1. The Center for the Health Sciences, The University of Tennessee Memorial Research Center, 37920, Knoxville, Tennessee

    Jane W. Ogle, R. D. Lange & C. D. R. Dunn

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  1. Jane W. Ogle
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  2. R. D. Lange
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  3. C. D. R. Dunn
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Additional information

This work was supported by Grants No. 74444 from The John A. Hartford Foundation, and HL 10567 from the National Institutes of Health.

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Ogle, J.W., Lange, R.D. & Dunn, C.D.R. Production of erythropoietin in vitro: A review. In Vitro 14, 945–950 (1978). https://doi.org/10.1007/BF02616125

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