Summary
Over the last 5 years, several authors have measured apparent affinities and maximal translocation rates of the different erythrocyte Na+ transport systems in essential hypertensive patients. These kinetic studies have clearly shown that no unique red cell Na+ transport defect characterizes the whole population of essential hypertensive patients. Conversely,several complex patterns of erythrocyte Na+ transport abnormalities may be present in different subsets of essential hypertensive patients. These kinetic studies are now providing a more profound biochemical insight into the molecular heterogeneity of primary hypertension. In particular, they may permit the diagnosis and specific treatment of different forms of primary hypertension in the next decade.
Similar content being viewed by others
References
Laragh J. Personal views on the mechanisms of hypertension. In: Genest J, Kuchel O, Hamet P, Cantin M, eds.Hypertension. New York: McGraw-Hill Book Company, 1983:615–631.
Garay R. Kinetic aspects of red blood cell sodium transport systems in essential hypertension.Hypertension 1987; 10(Suppl 1):11–14.
Canessa M, Brugnara C, Escobales N. The Li+−Na+ exchange and Na+, K+, Cl− cotransport systems in essential hypertension.Hypertension 1987;10(Suppl 1):4–10.
De La Sierra A, Coca A, Aguilera MT, Urbano A. Na+, K+ ATPase kinetics in a subsest of essential hypertensive patients.Eur J Clin Invest 1988;18:337–342.
Behr J, Witzgall H, Lorenz R, Weber PC, Duhm J. Red cell Na+, K+ transport in various forms of human hypertension. Role of cardiovascular risk factors and plasma potassium.Klin Wochenschr 1985;63(Suppl 3):63–65.
Mongeau JG. Erythrocyte cation fluxes in essential hypertension of children and adolescents.Int J Pediatr Nephrol 1985;6:41–46.
Garay R, Nazaret C, Dagher G, Marc JC, Bertrand E, Meyer P. Approche génétique de l'épidémiologie géographique de l'hypertension artérielle: Étude du cotransport Na+, K+ chez des Africains.Cardiologie Tropicale 1982; 8:49–54.
Canessa M, Spalvins A, Adragna N, Falkner B. Red cell sodium countertransport and cotransport in normotensive and hypertensive blacks.Hypertension 1984;6:344–351.
Tuck ML, Corry DB, Maxwell M, Stern N. Kinetic analysis of erythrocyte Na+, I+ pump and cotransport in essential hypertension.Hypertension 1987;10:204–211.
Rosati C, Meyer P, Garay R. Sodium transport kinetics in erythrocytes from spontaneously hypertensive rats.Hypertension 1988;11:41–48.
Cusi D, Barlassina C, Ferrari P, Ferrandi M, Bianchi G. Cation transport abnormalities in human and rat essential hypertension. In: Villareal H, Sambhi MP, eds.Topics in pathophysiology of hypertension, Boston: Martinus-Nijhoff, 1984:136–146.
Saitta M, Hannaert P, Rosati C, Meyer P, Garay R. A kinetic analysis of inward Na+, K+ cotransport in erythrocytes from spontaneously hypertensive rats.J Hypertens 1987;75(Suppl 5):S285-S286.
Adragna N, Canessa M, Solomon H, Slater E, Tosteson DC. Red cell lithium-sodium countertransport and sodium-potassium cotransport in patients with essential hypertension.Hypertension 1982;4:795–804.
De Mendonça M, Knorr A, Grichois ML, Ben-Ishay D, Garay D, Meyer P. Erythrocytic sodium ion transport systems in primary and secondary hypertension of the rat.Kidney Int 1982;21(Suppl 11):S69-S75.
Wauquier I, Pernollet MG, Grichois ML, Lacour B, Meyer P, Devynck MA. Endogenous digitalislike circulating substances in spontaneously hypertensive rats.Hypertension 1988;12:108–116
DeWardener HE, Clarkson EM. Concept of natriuretic hormone.Physiol Rev 1985;65:658–759.
Dagher G, Brossard M, Féray JC, Garay R. Modulation of erythrocyte Na transport pathway(s) by excess Na intake.Life Sci 1985;37:243–253.
Weder AB, Fitzpatrick A, Torretti BA, Hinderliter AL, Egan BM, Julius S. Red blood cell Li+−Na+ countertransport, Na+, K+ cotransport, and the hemodynamics of hypertension.Hypertension 1987;9:459–466.
Folkow B. The structural cardiovascular factor in primary hypertension-pressure dependence and genetic reinforcement.J Hypertens 1986;(Suppl 3):S51–56.
Vandewalle A, Forman N, Bonvalet JP. Renal handling of sodium in Kyoto-Okamoto rats: A micropuncture study.Am J Physiol 1978;235:F394-F420.
Takagi M. Study on relationship between sodium metabolism and prostaglandin in spontaneously hypertensive rats.J Tokyo Womens Med Coll 1985;55:116–228.
Harap SB, Doyle AE. Renal hemodynamics and total body sodium in immature spontaneously hypertensive and Wistar Kyoto rats.J Hypertens 1986;(Suppl 3):S249-S252.
Brugnara C, Corrocher R, Foroni L, Steinmayer M, Bonfanti F, De Sandre G. Lithium-sodium countertransport in erythrocytes of normal and hypertensive subjects: Relationship with age and plasma renin activity.Hypertension 1983;5:529–534.
Senn N, Ollivier JP, Abitbol JP, Garay R. Effet antihypertenseur du captopril, de l'hydrochlorotiazide, seuls ou en association, chez différentes catégories de malades hypertendus essentials.Arch Mal Coeur 1988;81(Suppl HTA):155–158.
Garay R, Nazaret C, Hannaert P, Deschamps de Paillette E, Juin G, Braquet P. Correlation between blood pressure and stimulation of K+ fluxes in essential hypertensive patients treated for two years with cicletanine.J Hypertens 1986;4(Suppl 5):S208-S209.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Garay, R. Typology of Na+ transport abnormalities in erythrocytes from essential hypertensive patients. A first step towards the diagnosis and specific treatment of different forms of primary hypertension. Cardiovasc Drug Ther 4 (Suppl 2), 373–378 (1990). https://doi.org/10.1007/BF02603179
Issue Date:
DOI: https://doi.org/10.1007/BF02603179