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Coxsackievirus B infection in the mouse: Effects associated with the diabetes gene, db

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Abstract

Coxsackievirus B4 (CB4) replicated to equally high titers in the pancreas and other tissues of the C57BL/Ks (+/+) mouse and its genetic variants that were either heterozygous (db/+) or homozygous (db/db) for the autosomal recessive gene for diabetes, db. In contrast, the insulin-producing beta cells of both diabetic variants, but not the +/+ mice, completely degranulated during acute infection and resulted in hypoglycemia and hyperinsulemia. All db/db mice died within 13 days, with signs of severe endocrine pancreas involvement. Surviving +/+ mice maintained relatively normal glucose homeostasis. Surviving db/+ variants exhibited prolonged periods of diabetes-like disease with hypoinsulemia and abnormal glucose tolerance, even though the db gene is not phenotypically expressed in the heterozygous state.

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Authors and Affiliations

  1. Department of Biology, Virginia Commonwealth University, 23284, Richmond, Virginia, USA

    S. R. Webb

  2. Department of Microbiology, Virginia Commonwealth University, 23284, Richmond, Virginia, USA

    R. M. Loria

  3. Department of Academic Pathology, Virginia Commonwealth University, 23284, Richmond, Virginia, USA

    G. E. Madge

  4. Department of Microbiology and Pediatrics, Boston University School of Medicine, 02118, Boston, Massachusetts, USA

    Sidney Kibrick

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  1. S. R. Webb
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  2. R. M. Loria
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  3. G. E. Madge
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  4. Sidney Kibrick
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Webb, S.R., Loria, R.M., Madge, G.E. et al. Coxsackievirus B infection in the mouse: Effects associated with the diabetes gene, db. Current Microbiology 3, 15–19 (1979). https://doi.org/10.1007/BF02603127

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