Abstract
Pseudomonas aeruginosa depresses contact sensitivity to oxazolone in mice by activating B suppressor cells within the lymph nodes that drain the site of sensitization. These suppressor cells affect the induction phase of the immune response by blocking the cooperation between “stimulator” macrophages and “initiator” T cells on one hand and “recruited” T cells on the other.
Similar content being viewed by others
Literature Cited
Asherson, G. L., Zembala, M., Mayhew, B. 1977. Analysis of the induction phase of contact sensitivity by footpad transfer of regional lymph node cells. Macrophages and radioresistant T lymphocytes induce immunity. Immunology32:81–88.
Bjornson, A. B., Michael, J. J. 1970. Biological activities of rabbit immunoglobulin M and immunoglobulin G antibodies toPseudomonas aeruginosa Infection and Immunity2:453–461.
Campa, M., Garzelli, C., Falcone, G. 1975. Depression of contact sensitivity and enhancement of antibody response inPseudomonas aeruginosa-infected mice. Infection and Immunity12:1252–1257.
Colizzi, V., Garzelli, C., Campa, M., Falcone, G. 1978. Depression of contact sensitivity by enhancement of suppressor cell activity inPseudomonas aeruginosa-injected mice. Infection and Immunity21:354–359.
Floersheim, G. L., Hopff, W. H., Gasser, M., Bucker, K. 1971. Impairment of cell-mediated immune response byPseudomonas aeruginosa. Clinical and Experimental Immunology9:241–247.
Garzelli, C., Colizzi, V., Campa, M., Bozzi, L., Falcone, G. 1979. Depression of the antibody response inPseudomonas aeruginosa-injected mice. Infection and Immunity24:32–38.
Gill, H. K., Liew, F. Y. 1979. Regulation of delayed-type hypersensitivity. IV. Antigen-specific suppressor cells for delayed-type hypersensitivity induced by lipopolysaccharide and sheep erythrocytes in mice. European Journal of Immunology9:101–106.
Munster, A. M., Leary, A. G. 1977. Cell-mediated immune response toPseudomonas aeruginosa. American Journal of Surgery133:710–712.
Raff, M. C. 1969. Theta isoantigen as marker of thymus-derived lymphocytes in mice. Nature224:378–379.
Reynolds, H. Y. 1974. Pulmonary host defenses in rabbits after immunization withPseudomonas antigens: The interaction of bacteria, antibodies, macrophages, and lymphocytes. Journal of Infectious Diseases130:S134-S142.
Stone, H. H., Given, K. S., Martin, J. D., Jr. 1967. Delayed rejection of skin homografts inPseudomonas sepsis. Surgery Gynecology and Obstetrics124:1067–1070.
Trizio, M. C., Cudkowicz, G. 1974. Separation of T and B lymphocytes by nylon wool columns: Evaluation of efficacy by functional assayin vivo. Journal of Immunology113:1093–1097.
Woodruff, M. F. A., Nolan, B., Robson, J. S., MacDonald, M. K. 1969. Renal transplantation in man. Lanceti:6–12.
Young, L. S. 1974. Role of antibody in infections due toPseudomonas aeruginosa. Journal of Infectious Diseases130:S111-S118.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Campa, M., Colizzi, V., Garzelli, C. et al. Pseudomonas aeruginosa infection: Activation of B suppressor cells which affect cell cooperation in the induction phase of contact sensitivity to oxazolone in mice. Current Microbiology 4, 173–175 (1980). https://doi.org/10.1007/BF02602824
Issue Date:
DOI: https://doi.org/10.1007/BF02602824