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A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma

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Abstract

Previous reports have described antigens that are recognized on human melanoma cells by autologous cytolytic T lymphocytes (CTL). The genes coding for a number of these antigens have been identified. Here we report the cloning of a gene that codes for an antigen recognized by autologous CTL on a human renal carcinoma cell line. This antigen is presented byHLA-B7 and is encoded by a new gene that we have namedRAGE1. No expression ofRAGE1 was found in normal tissues other than retina. RAGE1 expression was found in only one of 57 renal cell carcinoma samples, and also in some sarcomas, infiltrating bladder carcinomas, and melanomas. This represents the first identification of an antigen recognized by autologous CTL on a renal tumor.

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Authors and Affiliations

  1. Ludwig Institute for Cancer Research, Brussels Branch, UCL 7459, 74 avenue Hippocrate, B1200, Brussels, Belgium

    Béatrice Gaugler, Valérie Vantomme, Jean-Pierre Szikora, Jean-Jacques Patard, Thierry Boon & Benoît J. Van den Eynde

  2. Cellular Genetics Unit, Université Catholique de Louvain, B12GO, Brussels, Belgium

    Nathalie Brouwenstijn, Corry W. Van der Spek & Peter Schrier

  3. Dept of Clinical Oncology, Academic Hospital Leiden, Box 9600O, 2300 RC, Leiden, The Netherlands

    Nathalie Brouwenstijn, Corry W. Van der Spek & Peter Schrier

Authors
  1. Béatrice Gaugler
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  2. Nathalie Brouwenstijn
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  3. Valérie Vantomme
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  4. Jean-Pierre Szikora
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  5. Corry W. Van der Spek
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  6. Jean-Jacques Patard
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  7. Thierry Boon
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  8. Peter Schrier
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  9. Benoît J. Van den Eynde
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Gaugler, B., Brouwenstijn, N., Vantomme, V. et al. A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma. Immunogenetics 44, 323–330 (1996). https://doi.org/10.1007/BF02602776

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  • DOI: https://doi.org/10.1007/BF02602776

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