Abstract
The ability to develop type II collagen (CII)-induced arthritis (CIA) in mice is associated with the major histocompatibilityI-A gene and with as yet poorly defined regulatory molecules of the major histocompatibility complex (MHC) class II antigen processing and presentation pathway. H2-M molecules are thought to be involved in the loading of antigenic peptides into the MHC class II binding cleft. We sequencedH2-Ma, H2-Mb1, andH2-Mb2 genes from CIA-susceptible and-resistant mouse strains and identified four differentMa andMb2 alleles and three differentMb1 alleles defined by polymorphic residues within the predicted peptide binding groove. Most CIA-resistant mouse strains share commonMa, Mb1, andMb2 alleles. In contrast,H2-M alleles designatedMa-III,Ma-IV,Mb1-III, andMb2-IV could be exclusively identified in the CIA-susceptibleH2 r andH2 q haplotypes, suggesting that allelic H2-M molecules may modulate the composition of different CII peptides loaded onto MHC class II molecules, presumably presenting “arthritogenic” epitopes to T lymphocytes.
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The nucleotide sequence data reported in this paper have been submitted to the EMBL nucleotide sequence database and have been assigned the accession numbers X90783-X90964 and X90963 (H2-Ma), X90964-X90975 (H2-Mb1), and X90795-X90808 (H2-Mb2)
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Walter, W., Loos, M. & Maeurer, M.J. H2-M polymorphism in mice susceptible to collagen-induced arthritis involves the peptide binding groove. Immunogenetics 44, 19–26 (1996). https://doi.org/10.1007/BF02602653
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DOI: https://doi.org/10.1007/BF02602653