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Multimodale Therapien bei bronchuskarzinomen

Multimodality treatment of lung cancer

  • Themenschwerpunkt: Onkologische Thoraxchirurgie
  • Published:
Acta Chirurgica Austriaca Aims and scope Submit manuscript

Zusammenfassung

Grundlagen

Bei Patienten mit operablen Bronchuskarzinomen kommt es trotz Operation häufig zu lokalen und systemischen Rezidiven. Für die Prognose sind somit lokale und systemische Therapien von wesentlicher Bedeutung. Die Behandlung sowohl des nichtkleinzelligen als auch des kleinzelligen Bronchuskarzinoms erfolgt deshalb zunehmend mittels multimodaler Konzepte, die sowohl lokale Therapiemaßnahmen als auch die systemische Chemotherapie inkludieren.

Methodik

Als Lokaltherapie eignen sich die Operation und/oder Radiotherapie. Die systemische Chemotherapie erfolgt häufig mittels cisplatinhältiger Protokolle.

Ergebnisse

Bei lokal fortgeschrittenen nichtkleinzelligen Bronchuskarzinomen kann die Prognose durch Induktionschemotherapien mit anschließender Operation im Vergleich zur alleinigen Operation verbessert werden. Auch die postoperative adjuvante Chemotherapie mit neuen Zytostatika und verbesserten supportiven Maßnahmen dürfte in Zukunft zu einer Verbesserung der Prognose bei Patienten mit operablen nichtkleinzelligen Bronchuskarzinomen führen. Das kleinzellige Bronchuskarzinom wird ebenfalls meist mittels multimodaler Konzepte, die die Operation in den Frühstadien inkludieren, behandelt.

Schlußfolgerungen

Multimodale Therapiekonzepte in Verbindung mit neuen Zytostatika und verbesserten supportiven Therapien dürften zu einer Verbesserung der Prognose von Patienten mit Bronchuskarzinomen führen.

Summary

Background

Treatment of stage I–III lung cancer requires both local control of the disease and systemic treatment of micrometastatic disease. Thus multimodality treatment approaches are increasingly used for the treatment of lung cancer.

Methods

Local therapy includes surgery with and without radiotherapy. Systemic therapy is performed with preferentially cisplatin containing chemotherapy protocols.

Results

Induction chemotherapy with subsequent surgery has resulted in improved outcome of patients with stage III non-small cell lung cancer as compared to surgery alone. In patients with stage I–IIIA non-small cell lung cancer, postoperative adjuvant chemotherapy with better supportive care and new anticancer drugs might improve the survival of patients. Small cell lung cancer is also frequently treated by a multimodality approach that includes surgery in early disease stages.

Conclusions

Multimodality approaches are increasingly used in the treatment of lung cancer and should improve the outcome of patients with lung cancer.

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Authors and Affiliations

  1. Universität für Chirurgie, Innsbruck

    G. M. Salzer

  2. Klinische Abteilung für Onkologie, Universitätsklinik für Innere Medizin I, Währinger Gürtel 18-20, A-1090, Wien

    Sabine Zöchbauer, G. Krajnik,  R. Pirker & H. Huber

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  1. Sabine Zöchbauer
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  2. G. M. Salzer
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  3. G. Krajnik
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  4. R. Pirker
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  5. H. Huber
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Zöchbauer, S., Salzer, G.M., Krajnik, G. et al. Multimodale Therapien bei bronchuskarzinomen. Acta Chir Austriaca 28, 78–82 (1996). https://doi.org/10.1007/BF02602606

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  • DOI: https://doi.org/10.1007/BF02602606

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