Zusammenfassung
Eine Übersicht über die bisherigen klinischen Erfahrungen mit nieder-molekularen Heparinen in der Allgemeinchirurgie führt zu dem Ergebnis, daß mit nur 1mal täglicher Gabe von niedermolekularem Heparin eine mindestens ebenbürtige antithrombotische Effizienz wie unter herkömmlicher Low-dose-Heparinprophylaxe erreicht werden kann, bei welcher durch die mehrfach applizierten Injektionen eine 2- oder 3mal tägliche Belästigung von Patienten und Pflegepersonal in Kauf genommen werden muß. Auch die Verträglichkeit von niedermolekularen Heparinen gegenüber unfraktioniertem Heparin scheint gleich zu sein.
Summary
Numerous clinical studies in patients undergoing general surgery have provided evidence that the antithrombotic activity of single daily injections of low molecular weight heparins are at least equipotent as b.i.d. or t.i.d. injections of unfractionated heparin. Thereby, the stress of the patient can be appreciably reduced and the nursing staff is spared a great deal of work. Also tolerance of low molecular weight heparin prophylaxis seems to be comparable with that of conventional heparin.
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Haas, S., Blümel, G. Thromboseprophylaxe mit niedermolekularen Heparinen in der Allgemeinchirurgie. Acta Chir Austriaca 24, 159–162 (1992). https://doi.org/10.1007/BF02601922
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DOI: https://doi.org/10.1007/BF02601922