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Viral-specific antigen synthesis following de novo RD-114 virus infection of stationary cells

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Abstract

The cell cycle dependence of retrovirus replication was studied. Canine sarcoma (D-17) cells were infected de novo with the xenotropic feline retrovirus RD-114 under conditions previously reported to simultaneously inhibit virus replication and cell DNA synthesis and/or cell division. RD-114 viral antigen synthesis was observed under conditions previously reported to be inhibitory to avian and murine oncornavirus replication, including confluency and serum deprivation, X-irradiation, mitomycin C pretreatment, colchicine, and ethidium bromide treatments of cells. Several mechanisms that could account for viral antigen synthesis under the restrictive conditions used are discussed.

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Authors and Affiliations

  1. Department of Bacteriology, University of California, 95616, Davis, California, USA

    Wynne G. Lewis & JaRue S. Manning

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  1. Wynne G. Lewis
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  2. JaRue S. Manning
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Lewis, W.G., Manning, J.S. Viral-specific antigen synthesis following de novo RD-114 virus infection of stationary cells. Current Microbiology 2, 233–238 (1979). https://doi.org/10.1007/BF02601719

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