Abstract
The activity of the combination rifampin plus trimethoprim againstHaemophilus influenzae was studied from the point of view of synergism, bactericidal activity, and inhibition of the selection of rifampin-resistant cells. At concentrations of the two drugs that are easily attainable in human serum after oral treatment with 600 mg of rifampin plus 160 mg of trimethoprim, the combination acted synergistically on all of the strains tested, was remarkably bactericidal, and inhibited the selection of rifampin-resistant cells.
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Berti, M., Scotti, R., Ripamonti, F. et al. Activity of rifampin plus trimethoprim againstHaemophilus influenzae . Current Microbiology 2, 223–225 (1979). https://doi.org/10.1007/BF02601717
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DOI: https://doi.org/10.1007/BF02601717