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The effect of lactinex on rabbit ileal loop reactions induced by enterotoxigenicEscherichia coli

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Abstract

The effect of Lactinex, a lactobacillus-containing pharmaceutical, on rabbit ileal loop reactions induced by enterotoxigenicEscherichia coli was studied. Lactinex granules, tablets, or its separate components were mixed and incubated in vitro with toxigenicE. coli prior to injection into ileal loops. Since inocula were free of preformed enterotoxin, reactions indicated in vivo enterotoxin production. Lactinex granules reduced loop fluid when compared with that induced by the positive control (P<0.001) or inocular containing Lactinex tablets (P=0.009). Whey powder, 109 and 107 Lactobacillus acidophilus, and 108 Lactobacillus bulgaricus were the only Lactinex components that significantly reduced loop fluid.

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Authors and Affiliations

  1. Infectious Diseases Laboratory (151), Veterans Administration Medical Center, 3900 Loch Raven Boulevard, 21218, Baltimore, Maryland, USA

    David E. Johnson

  2. Division of Infectious Diseases, University of Maryland School of Medicine, 22 South Greene Street, 21201, Baltimore, Maryland, USA

    Frank M. Calia

Authors
  1. David E. Johnson
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  2. Frank M. Calia
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Johnson, D.E., Calia, F.M. The effect of lactinex on rabbit ileal loop reactions induced by enterotoxigenicEscherichia coli . Current Microbiology 2, 207–210 (1979). https://doi.org/10.1007/BF02601713

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